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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Soilleux, Elizabeth Eyre, Toby Andrew Collins, Graham P. Zhang, Xiao-yin |
| Description | Author Affiliation: Zhang XY ( Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK.); Collins GP ( Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK.); Soilleux E ( Department of Cellular Pathology, Oxford University Hospitals NHS Trust, Oxford, UK.); Eyre TA ( Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK.) |
| Abstract | Histological features of Epstein-Barr virus (EBV) can rarely mimic lymphoma. A 25-year-old presented with a spontaneous splenic rupture following a short illness. Histopathology assessment of the splenic and marrow tissue was highly suggestive of peripheral T-cell lymphoma not-otherwise-specified (PTCL-NOS). T-cell receptor (TCR) PCR clonality studies revealed a monoclonal T-cell population expressing for both TCRß and γ, strongly suggestive of a T-cell clonal disease. EBV IgM was positive and IgG negative. EBV PCR was positive (7.02 ×10(4)/mL). Despite the strong suggestion of PTCL-NOS from histopathology and clonality studies, the decision was made to observe the patient and not start multiagent chemotherapy. The patient remained well, with no signs of PTCL and subsequently seroconverted to IgG+ EBV. We highlight the potential pitfall of acute EBV masquerading as PTCL and show the critical role of the multidisciplinary integration of histopathological, serology, molecular and clinical features to avoid misdiagnosis. |
| Volume Number | 2016 |
| e-ISSN | 1757790X |
| Journal | BMJ Case Reports |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Epstein-Barr Virus Infections Diagnosis Lymphoma, T-Cell, Peripheral Adult Antibodies, Monoclonal Blood Diagnosis, Differential Virology Herpesvirus 4, Human Immunology Humans Male Receptors, Complement 3d Case Reports Journal Article Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
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