NDLI: Brain-derived fibroblast growth factor: identity with a fragment of the basic protein of myelin.

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Brain-derived fibroblast growth factor: identity with a fragment of the basic protein of myelin.

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Brain-derived fibroblast growth factor: identity with a fragment of the basic protein of myelin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gospodarowicz, D. Lennon, V. A. Westall, F. C.
Abstract	Fibroblast growth factors (FGF) isolated from bovine brain have been identified chemically and immunologically as components of the myelin basic protein. The intact bovine basic protein molecule (170 residues), prepared by the standard acid extraction procedure, lacked mitogenic activity (tested at concentrations up to 10 microgram/ml). However, the polypeptide FGF-2, identified as residues 44-153 of the basic protein, was maximally mitogenic for fibroblasts at 10 ng/ml and polypeptide 44-166 (FGF-1) was maximally active at 100 ng/ml. Pituitary-derived FGF is a potent a growth factor as FGF-2, but appears to be biochemically and immunologically distinct from brain-derived FGF. FGF released in the central or peripheral nervous system as a consequence of myelin damage and basic protein proteolysis could provide a physiological stimulus for wound healing and myelin repair.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	75
Language	English
Publisher	National Academy of Sciences
Publisher Date	1978-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Chemistry Growth Substances Myelin Basic Protein Amino Acid Sequence Animals Cross Reactions Fibroblasts Drug Effects Immunology Pharmacology Mitogens Pituitary Gland Metabolism Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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