NDLI: Actinomycin D-deoxynucleotide interactions: binding isotherms at the benzenoid and quinoid portions of the drug.

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Actinomycin D-deoxynucleotide interactions: binding isotherms at the benzenoid and quinoid portions of the drug.

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Actinomycin D-deoxynucleotide interactions: binding isotherms at the benzenoid and quinoid portions of the drug.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Thompson, T. N. Auer, H. E.
Abstract	Titrations of actinomycin D (AMD) with dG and with dG-dC were monitored by circular dichroism at 380 nm and 470 nm. These wavelengths are sensitive predominantly to nucleotide binding processes at the benzenoid and quinoid portions, respectively, of the phenoxazone ring of the drug chromophore [Auer, H.E., Pawlowski-Konopnicki, B.E., Chiao, Y.C.C. & Krugh, T.R. (1978), Biopolymers, 17, 1891-1911.]. The temperature dependence of these isotherms was analyzed by the van't Hoff equation to obtain values for the enthalpy and entropy changes. For dG these are about -11 kcal mol-1 and -20 cal mol-1 deg-1, respectively, for complex formation at both the benzenoid and quinoid sites (1 cal = 4.184 J). The enthalpy and entropy changes for complex formation with dG-dC remain unchanged at the benzenoid site, but both values are more negative at the quinoid site. These results indicate that the additional process of binding C in the intercalated AMD-(dG-dC)2 complex, with respect to the simply stacked AMD-dG2 complex, has distinctive properties at the two sites, reflecting their structural differences. The ability to resolve binding processes at the two sites by circular dichroism has permitted us to suggest assignments for the two 31P magnetic resonance lines from the phosphodiester groups observed in the AMD-(pdG-dC)2 complex.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	75
Language	English
Publisher	National Academy of Sciences
Publisher Date	1978-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dactinomycin Metabolism Deoxyribonucleotides Binding Sites Circular Dichroism Deoxycytosine Nucleotides Deoxyguanine Nucleotides Temperature Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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