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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Londos, C. Wolff, J. Cooper, D. M. |
| Abstract | Cell surface adenosine receptors mediate either stimulation or inhibition of adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], and the receptors that mediate these different responses can be discriminated with selected adenosine analogs. 5'-N-Ethylcarboxamide-adenosine is a more potent agonist at stimulatory receptors (Ra) than is N6-phenylisopropyladenosine, whereas the reverse potency order is seen with inhibitory receptors (Ri). The potency of adenosine is intermediate between the potencies of these two analogs. The relative potencies of adenosine receptor agonists are maintained in physiological responses in intact cells, such as steroidogenesis and inhibition of lipolysis. As with adrenergic receptors, subclasses of adenosine receptors differ functionally and pharmacologically. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 5 |
| Volume Number | 77 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1980-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adenosine Metabolism Adenylate Cyclase Receptors, Cell Surface Analogs & Derivatives Classification Adenylyl Cyclase Inhibitors Adipose Tissue Animals Enzyme Activation Drug Effects Glycerol Biosynthesis Leydig Cells Liver Receptors, Purinergic Steroids Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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