NDLI: Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1983 Volume: 80 Issue: 24

Year: 1983 Volume: 80 Issue: 23

Year: 1983 Volume: 80 Issue: 22

Year: 1983 Volume: 80 Issue: 21

Year: 1983 Volume: 80 Issue: 20

Year: 1983 Volume: 80 Issue: 19

Year: 1983 Volume: 80 Issue: 18

Year: 1983 Volume: 80 Issue: 17

Year: 1983 Volume: 80 Issue: 16

Year: 1983 Volume: 80 Issue: 15

Year: 1983 Volume: 80 Issue: 14

Role of microtubules in the distribution of the Golgi apparatus: effect of taxol and microinjected anti-alpha-tubulin antibodies.

Topography of transcription: path of the leading end of nascent RNA through the Escherichia coli transcription complex.

Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin.

Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma.

Selection of functional cDNAs by complementation in yeast.

Identification of a precursor molecular for the RNA moiety of the processing enzyme RNase P.

Suspension culture of human mast cells/basophils from umbilical cord blood mononuclear cells.

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.

Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains.

Immunohistochemical localization of monoclonal antibodies to the nicotinic acetylcholine receptor in chick midbrain.

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

In vitro synthesis of bacteriophage phi X174 by purified components.

Identification of homo-oligomers as potential intermediates in acetylcholine receptor subunit assembly.

(Dichloromethylene)diphosphonate-induced impairment of T-lymphocyte function.

Thymotropism of murine leukemia virus is conferred by its long terminal repeat.

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

The FLP protein of the yeast 2-microns plasmid: expression of a eukaryotic genetic recombination system in Escherichia coli.

Molecular cloning of a vitamin D-dependent calcium-binding protein mRNA sequence from chick intestine.

Biphasic regulation by dibutyryl cyclic AMP of tubulin and actin mRNA levels in neuroblastoma cells.

Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins.

Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.

In vitro assembly of a pre-messenger ribonucleoprotein.

Genomic environment of variant surface antigen genes of Trypanosoma equiperdum.

Gating of ion channels made by a diphtheria toxin fragment in phospholipid bilayer membranes.

Visualization of antigens attached to cytoskeletal framework in animal cells: colocalization of simian virus 40 Vp1 polypeptide and actin in TC7 cells.

Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

Expression of the large T protein of polyoma virus promotes the establishment in culture of 'normal' rodent fibroblast cell lines.

Analyses of bromodeoxyuridine-associated sister chromatid exchanges (SCEs) in Bloom syndrome based on cell fusion: single and twin SCEs in endoreduplication.

Detection of an altered DNA conformation at specific sites in chromatin and supercoiled DNA.

Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast.

Role for the 3' end of the genome in determining disease specificity of Friend and Moloney murine leukemia viruses.

Yeast recombination: the association between double-strand gap repair and crossing-over.

F sex factor of Escherichia coli K-12 codes for a single-stranded DNA binding protein.

Open reading frame expression vectors: a general method for antigen production in Escherichia coli using protein fusions to beta-galactosidase.

Molecular cloning and characterization of the gene coding for human complement protein factor B.

Efficient generation in vitro, from human peripheral blood cells, of monoclonal Epstein-Barr virus transformants producing specific antibody to a variety of antigens without prior deliberate immunization.

Reconstitution in vitro of neurotoxin-responsive ion efflux by using membrane glycoproteins of neuroblastoma cells.

Localization of prostaglandin D2 binding protein and NADP-linked 15-hydroxyprostaglandin D2 dehydrogenase in the Purkinje cells of miniature pig cerebellum.

Testing an alternative model for the ribosomal peptide elongation cycle.

NMR study of slowly exchanging imino protons in yeast tRNAasp.

Targeted mutation at cytosine-containing pyrimidine dimers: studies of Escherichia coli B/r with acetophenone and 313-nm light.

Stimulation of mucosal mast cell growth in normal and nude rat bone marrow cultures.

Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment.

Protein-primed initiation of phage phi 29 DNA replication.

Cloning of human purine-nucleoside phosphorylase cDNA sequences by complementation in Escherichia coli.

Regulation of carbohydrate metabolism by 2,5-anhydro-D-mannitol.

Left-handed Z-DNA in bands of acid-fixed polytene chromosomes.

Polymorphic gene for human carbonic anhydrase II: a molecular disease marker located on chromosome 8.

cDNA clone encoding a complete rabbit immunoglobulin kappa light chain of b4 allotype.

Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins.

Psychological stress activates phosphorylase in the heart of the conscious pig without increasing heart rate and blood pressure.

Steady-state kinetic study of fatty acid synthase from chicken liver.

Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.

Molecular cloning of the cDNA coding for rat ornithine transcarbamoylase.

Detection of a guanine X adenine base pair in a decadeoxyribonucleotide by proton magnetic resonance spectroscopy.

Growth-related changes in specific mRNAs of cultured mouse cells.

Activation of calcineurin by limited proteolysis.

Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data.

New view of lipid bilayer dynamics from 2H and 13C NMR relaxation time measurements.

Phorbol ester inhibits furosemide-sensitive potassium transport in BALB/c 3T3 preadipose cells.

Immunocytochemical localization of alpha-D-mannosidase II in the Golgi apparatus of rat liver.

Comparison of secretory protein and membrane composition of secretory granules isolated from normal and neoplastic pancreatic acinar cells of rats.

Early epochal maps of two different cell adhesion molecules.

Birds, behavior, and anatomical evolution.

Trans-acting temporal locus within the beta-glucuronidase gene complex.

Chromosomal assignment of a family of human oncogenes.

Idiotypic manipulation in mice: BALB/c mice can express the crossreactive idiotype of A/J mice.

Nickel-sequestering renal glycoprotein.

Attenuation of Mach bands by adjacent stimuli.

Discovery, invention, and development: human creative thinking.

Research and invention.

Evidence for the general base mechanism in carboxypeptidase A-catalyzed reactions: partitioning studies on nucleophiles and H2(18)O kinetic isotope effects.

Identification of the molecular defect in factor IX Chapel Hill: substitution of histidine for arginine at position 145.

Naturally occurring cytotoxic human antibodies recognize H-2-controlled murine lymphocyte antigens.

Year: 1983 Volume: 80 Issue: 13

Year: 1983 Volume: 80 Issue: 12

Year: 1983 Volume: 80 Issue: 11

Year: 1983 Volume: 80 Issue: 10

Year: 1983 Volume: 80 Issue: 9

Year: 1983 Volume: 80 Issue: 8

Year: 1983 Volume: 80 Issue: 7

Year: 1983 Volume: 80 Issue: 6

Year: 1983 Volume: 80 Issue: 5

Year: 1983 Volume: 80 Issue: 4

Year: 1983 Volume: 80 Issue: 3

Year: 1983 Volume: 80 Issue: 2

Year: 1983 Volume: 80 Issue: 1

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Talalay, P. Penning, T. M.
Abstract	A NAD(P)-linked 3 alpha-hydroxysteroid dehydrogenase [3 alpha-hydroxysteroid: NAD(P) oxidoreductase, EC 1.1.1.50], purified to homogeneity from male rat liver cytosol, accounts for most of the oxidative activity for 3 alpha-hydroxysteroids and for benzenedihydrodiol (trans-1,2-dihydroxy-3,5-cyclohexadiene) of this tissue. This enzyme, which also promotes the reduction of quinones and certain aromatic aldehydes and ketones, is powerfully inhibited by the major types of nonsteroidal and steroidal anti-inflammatory drugs. The IC50 values for indomethacin and for betamethasone are in the low micromolar range. The rank order of the inhibitory potencies of a series of these agents paralleled closely that reported for the inhibition of cyclooxygenase by nonsteroidal anti-inflammatory agents or the indirect inhibition of phospholipase A2 by anti-inflammatory steroids. A good correlation is found also between the logarithm of the concentrations of these drugs required to inhibit 3 alpha-hydroxysteroid dehydrogenase and the human anti-inflammatory dose. The suggestion that this enzyme may play a role in mediating inflammation is further strengthened by the observation that the dehydrogenase binds arachidonic acid and is also potentially inhibited by certain prostaglandins. This enzyme may be of use in the evaluation of anti-inflammatory activity.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	80
Language	English
Publisher	National Academy of Sciences
Publisher Date	1983-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	3-Hydroxysteroid Dehydrogenases Antagonists & Inhibitors Adrenal Cortex Hormones Pharmacology Anti-Inflammatory Agents Liver Enzymology Prostaglandins 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) Animals Cyclooxygenase Inhibitors Cytosol Kinetics Molecular Conformation Rats, Inbred Strains Structure-Activity Relationship Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in