NDLI: Gating of ion channels made by a diphtheria toxin fragment in phospholipid bilayer membranes.

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Gating of ion channels made by a diphtheria toxin fragment in phospholipid bilayer membranes.

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Gating of ion channels made by a diphtheria toxin fragment in phospholipid bilayer membranes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Misler, S.
Abstract	B45, a fragment containing the major hydrophobic region of diphtheria toxin, increases the conductance of thin lipid membranes by forming ion-conducting channels that are gated by transmembrane voltage, Vm, and the bath pH. Single-channel currents show 'bursting' behavior in the form of rapid transitions between a closed and an open conductance level. The average duration of a current 'burst,' as well as the total time a channel is actually open within a burst, decreases with increasing Vm. Analysis of these data suggests that, over a range of Vm, increases in the rate constants for transitions from the open to the closed states largely account for the decline in macroscopic conductance with increasing Vm. Increases in rate constants for transitions from a closed to an open conductance state are more likely to account for the increase in macroscopic conductance with increasing bath pH. Since several diphtheria toxin fragments and mutants are currently available, each containing various portions of the B45 region, it may be possible to study the relationship of the structure of these complex proteins to the detailed gating properties of the ion channels that they form.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	80
Language	English
Publisher	National Academy of Sciences
Publisher Date	1983-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diphtheria Toxin Ion Channels Physiology Lipid Bilayers Electric Conductivity Kinetics Mathematics Models, Biological Peptide Fragments Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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