NDLI: Autocrine growth inhibition of a cloned line of helper T cells.

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Autocrine growth inhibition of a cloned line of helper T cells.

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Autocrine growth inhibition of a cloned line of helper T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kaye, J. Janeway, C. A. Horowitz, J. B. Katz, M. E. Conrad, P. J.
Abstract	The growth of T lymphocytes is dependent on the T-cell growth factor interleukin 2 (IL-2), which causes T cells bearing high-affinity receptors for IL-2 to proliferate. Most cloned helper-T-cell lines can be shown to both produce and respond to IL-2; thus, growth of such cells is by an autocrine mechanism. We report that the failure of the cloned murine T-cell line D10.G4.1 to respond to its own IL-2 results from the secretion, by the same cells, of a potent inhibitor of the IL-2-driven T-cell proliferative response. This inhibition can be overcome by increasing the number of IL-2 receptors expressed by the target cell. In the cloned T-cell line producing the inhibitory substance, this increase in IL-2 receptors is driven by the monokine interleukin-1. We propose that this inhibitor of IL-2 responses may play a role in preventing 'bystander' activation of T cells by IL-2 released in vivo and could be a potent pharmacologic agent.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Growth Inhibitors Physiology Interleukin-2 T-Lymphocytes, Helper-Inducer Animals Antibodies, Monoclonal Immunology Cell Division Drug Effects Clone Cells Isolation & Purification Pharmacology Mice Mice, Inbred AKR Mice, Inbred BALB C Molecular Weight Receptors, Immunologic Receptors, Interleukin-2 Cytology Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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