NDLI: Model for clonal elimination in the thymus.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1989 Volume: 86 Issue: 24

Year: 1989 Volume: 86 Issue: 23

Year: 1989 Volume: 86 Issue: 22

Year: 1989 Volume: 86 Issue: 21

Year: 1989 Volume: 86 Issue: 20

Year: 1989 Volume: 86 Issue: 19

Year: 1989 Volume: 86 Issue: 18

Year: 1989 Volume: 86 Issue: 17

Year: 1989 Volume: 86 Issue: 16

Year: 1989 Volume: 86 Issue: 15

Year: 1989 Volume: 86 Issue: 14

Year: 1989 Volume: 86 Issue: 13

Year: 1989 Volume: 86 Issue: 12

Year: 1989 Volume: 86 Issue: 11

Year: 1989 Volume: 86 Issue: 10

OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.

Ribonuclease H activities associated with viral reverse transcriptases are endonucleases.

Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins.

Direct activation of cGMP-dependent channels of retinal rods by the cGMP phosphodiesterase.

A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami.

Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.

A synthetic peptide defines a serologic IgA response to a human papillomavirus-encoded nuclear antigen expressed in virus-carrying cervical neoplasia.

Activity of ion channels during volume regulation by clonal N1E115 neuroblastoma cells.

Plasmenylethanolamine is the major storage depot for arachidonic acid in rabbit vascular smooth muscle and is rapidly hydrolyzed after angiotensin II stimulation.

Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli.

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.

Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA.

Induction of diapause in Drosophila melanogaster: photoperiodic regulation and the impact of arrhythmic clock mutations on time measurement.

Genetic characterization of clones of the bacterium Listeria monocytogenes causing epidemic disease.

An estimate of the number of G regulator proteins activated per excited rhodopsin in living Limulus ventral photoreceptors.

Corticosterone differentially regulates the expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex.

Cadmium resistance from Staphylococcus aureus plasmid pI258 cadA gene results from a cadmium-efflux ATPase.

E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.

Genomic sequencing reveals a 5-methylcytosine-free domain in active promoters and the spreading of preimposed methylation patterns.

Specific inhibition of cell-surface T-cell receptor expression by antisense oligodeoxynucleotides and its effect on the production of an antigen-specific regulatory T-cell factor.

Model for clonal elimination in the thymus.

Plasmin catalyzes binding of lipoprotein (a) to immobilized fibrinogen and fibrin.

Mechanism of inhibition of growth of 3T3-L1 fibroblasts and their differentiation to adipocytes by dehydroepiandrosterone and related steroids: role of glucose-6-phosphate dehydrogenase.

Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli.

Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

Structural significance of an internal water molecule studied by site-directed mutagenesis of tyrosine-67 in rat cytochrome c.

Regulation of the iron uptake system in Vibrio anguillarum: evidence for a cooperative effect between two transcriptional activators.

Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.

Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.

Auxin-binding protein located in the endoplasmic reticulum of maize shoots: molecular cloning and complete primary structure.

Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro.

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.

Mechanism of regulation of the 422(aP2) gene by cAMP during preadipocyte differentiation.

GDP stimulates the phosphorylation of a 36-kDa membrane protein in Dictyostelium discoideum.

The current source of human Alu retroposons is a conserved gene shared with Old World monkey.

Phenotypes of rotavirus reassortants depend upon the recipient genetic background.

Calcium channel activity of purified human synexin and structure of the human synexin gene.

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages.

Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome.

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain.

Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis.

Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein.

Retrovirus-induced murine motor neuron disease: mapping the determinant of spongiform degeneration within the envelope gene.

Dendritic current flow in relay cells and interneurons of the cat's lateral geniculate nucleus.

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

Cloning and molecular characterization of the trithorax locus of Drosophila melanogaster.

Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification.

Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells.

Active transport of gamma-aminobutyric acid and glycine into synaptic vesicles.

Determinants of EcoRI endonuclease sequence discrimination.

A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

Genetic selection for genes encoding sequence-specific DNA-binding proteins.

Enhanced meiotic recombination on the smallest chromosome of Saccharomyces cerevisiae.

Nonrandom utilization of codon pairs in Escherichia coli.

Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.

von Willebrand factor synthesized by endothelial cells from a patient with type IIB von Willebrand disease supports platelet adhesion normally but has an increased affinity for platelets.

Biostatistical analysis of mortality data for cohorts of cancer patients.

Characterization of oligonucleotide transport into living cells.

Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors.

DNA strand breaks alter histone ADP-ribosylation.

Characterization of human cardiac myosin heavy chain genes.

Infectious in vitro transcripts from cloned cDNA of a potyvirus, tobacco vein mottling virus.

Deletion analysis of the maize mitochondrial superoxide dismutase transit peptide.

Landmark mapping: a general method for localizing cysteine residues within a protein.

Aspartyl beta-hydroxylase: in vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX.

Influence of abasic and anucleosidic sites on the stability, conformation, and melting behavior of a DNA duplex: correlations of thermodynamic and structural data.

Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III: implications for heparin efficacy.

Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal.

Molecular cloning and sequencing of a cDNA for plant calmodulin: signal-induced changes in the expression of calmodulin.

Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.

Mechanism of programmed cell death in the blastocyst.

S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C.

Lithium evokes expression of vegetal-specific molecules in the animal blastomeres of sea urchin embryos.

A glycosylation mutation affects cell fate in chimeras of Dictyostelium discoideum.

Anti-Müllerian hormone produces endocrine sex reversal of fetal ovaries.

Chlorambucil effectively induces deletion mutations in mouse germ cells.

Insertional mutation in a transgenic mouse allelic with Purkinje cell degeneration.

Saturation mutagenesis of the octopine synthase enhancer: correlation of mutant phenotypes with binding of a nuclear protein factor.

Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA.

Modeling sickle cell vasoocclusion in the rat leg: quantification of trapped sickle cells and correlation with 31P metabolic and 1H magnetic resonance imaging changes.

Role of early region 3 (E3) in pathogenesis of adenovirus disease.

Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.

Construction and use of a replication-competent human immunodeficiency virus (HIV-1) that expresses the chloramphenicol acetyltransferase enzyme.

Purification and characterization of glia maturation factor beta: a growth regulator for neurons and glia.

Coevolution of host and pathogen populations in the Hordeum vulgare-Rhynchosporium secalis pathosystem.

Use of Bacillus brevis for efficient synthesis and secretion of human epidermal growth factor.

Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.

Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptor.

Idiotypic cascades in cancer patients treated with monoclonal antibody CO17-1A.

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

Year: 1989 Volume: 86 Issue: 9

Year: 1989 Volume: 86 Issue: 8

Year: 1989 Volume: 86 Issue: 7

Year: 1989 Volume: 86 Issue: 6

Year: 1989 Volume: 86 Issue: 5

Year: 1989 Volume: 86 Issue: 4

Year: 1989 Volume: 86 Issue: 3

Year: 1989 Volume: 86 Issue: 2

Year: 1989 Volume: 86 Issue: 1

Specific photoaffinity labeling of two plasma membrane polypeptides with an azido auxin.

Phytochrome induces changes in the immunodetectable level of a wall peroxidase that precede growth changes in maize seedlings.

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Model for clonal elimination in the thymus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maruo, S. Kosaka, H. Hikita, I. Hamaoka, T. Ogata, M. Matsubara, H. Takai, Y. Sugihara, S. Fujiwara, H.
Description	Author Affiliation: Kosaka H ( Biomedical Research Center, Osaka University Medical School, Japan.);
Abstract	A thymic stromal cell clone, MRL104.8a, expresses class I as well as class II H-2k antigens after exposure to gamma-interferon. This clone also produces thymic stroma-derived T-cell growth factor (TSTGF), which is distinct from other known interleukins and is capable of promoting the growth of various antigen-specific helper T cell (Th) clones without requiring a specific antigen or interleukin 2. When the keyhole limpet hemocyanin (KLH)-specific, I-Ek-restricted Th clone 9-16 was cultured on an Ia (I-Ak and I-Ek)-expressing MRL104.8a monolayer, potent proliferation of the 9-16 cells was induced by TSTGF produced by the monolayer. In contrast, the addition of KLH resulted in lethal growth inhibition of Th clone 9-16 cells. Another Th clone that is KLH-specific but I-Ab-restricted was capable of proliferating on the Iak-expressing MRL104.8a monolayer whether or not KLH was present. More importantly, death of Th clone 9-16 cells cultured on a MRL104.8a monolayer in the presence of KLH was almost completely prevented by the addition of anti-I-Ek or anti-CD3 monoclonal antibodies, which are capable of blocking antigen recognition by the T-cell receptor. However, when Th clone 9-16 cells were cultured in the presence of KLH but on a monolayer of MRL28.8a cells, another thymic stromal clone that expresses a comparable amount of I-Ek antigen but produces a marginal amount of TSTGF, cells did not die; a lethal effect was induced by adding TSTGF. These results indicate that the TSTGF-producing and Ia-expressing thymic stromal cells induce the continuous proliferation or selective elimination of each T-cell clone, depending on whether the T-cell receptor is stimulated by the relevant antigen associated with Ia molecules expressed on the stromal cell surface.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Histocompatibility Antigens Class II Physiology Receptors, Antigen, T-Cell Thymus Gland Cytology Animals Antibodies, Monoclonal Pharmacology Cell Division Cells, Cultured Clone Cells Growth Substances In Vitro Techniques Mice Models, Biological T-Lymphocytes, Helper-Inducer Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in