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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Van De Rijn, M. Heimfeld, S. Spangrude, G. J. Weissman, I. L. |
| Description | Author Affiliation: van de Rijn M ( Department of Pathology, Stanford University School of Medicine, CA 94305.); |
| Abstract | Recently, hematopoietic stem cells were purified to homogeneity from mouse bone marrow. The protein structure of Sca-1, the cell surface antigen used in the isolation of hematopoietic stem cells, is described here. It is shown that the Sca-1 antigen is a member of the Ly-6 antigen family. The anti-Sca-1 antibody was used in immunohistochemistry experiments to define the structures in several tissues that had previously been shown to contain Ly-6 antigens. In thymus, spleen, and kidney, specific staining of parenchymal cells can be demonstrated, whereas only vasculature reacts with anti-Sca-1 in brain, heart, and liver and possibly in lung. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Ly Immunology Hematopoietic Stem Cells T-Lymphocytes Animals Antibodies, Monoclonal Genetics Bone Marrow DNA-Directed DNA Polymerase Fluorescent Antibody Technique Gene Amplification Immunoenzyme Techniques Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Sequence Data RNA, Messenger Spleen Transcription, Genetic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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