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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Neve, R. L. Bear, M. F. |
| Description | Author Affiliation: Neve RL ( Division of Genetics, Children's Hospital, Boston, MA.); |
| Abstract | We have examined the regulation of expression of the genes for the neuronal growth-associated protein GAP43, the type II calcium/calmodulin-dependent protein kinase, and glutamic acid decarboxylase in the kitten visual cortex during normal postnatal development and after a period of visual deprivation. We find that the mRNA transcripts of these genes display very different patterns of normal development but are all increased in the visual cortex of animals reared in the dark. Upon exposure to light, the transcript of the GAP43 gene drops to near-normal levels within 12 hr. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genes RNA, Messenger Genetics Transcription, Genetic Vision, Ocular Visual Cortex Growth & Development Aging Animals Blotting, Northern Calcium-Calmodulin-Dependent Protein Kinases GAP-43 Protein Glutamate Decarboxylase Growth Substances Membrane Proteins Nerve Tissue Proteins Protein Kinases Reference Values Physiology Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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