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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Anthony, D. D. Wentz, W. B. Reagan, J. W. Heggie, A. D. |
| Description | Author Affiliation: Anthony DD ( Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH.); |
| Abstract | Induction of cervical neoplasia in the mouse cervix by herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) has been reported. The present study was done to determine if transfection with DNA of HSV-2 can induce carcinogenesis in this animal model. Genomic HSV-2 DNA was isolated from infected HEp-2 cells and separated from host cell DNA by cesium chloride density gradient centrifugation. The DNA was applied to mouse cervix for periods of 80-100 weeks. Experimental controls were treated with uninfected genomic HEp-2 cell DNA or with calf thymus DNA. Vaginal cytological preparations from all animals were examined monthly to detect epithelial abnormalities. Animals were sacrificed and histopathology studies were done when cellular changes indicative of premalignant or malignant lesions were seen on vaginal smears. Cytologic and histologic materials were coded and evaluated without knowledge of whether they were from animals treated with virus or control DNA. Premalignant and malignant cervical lesions similar to those that occur in women were detected in 61% of the histologic specimens obtained from animals exposed to HSV-2 DNA. The yield of invasive cancers was 21% in animals treated with HSV-2 DNA. No cancers were detected in mice treated with either HEp-2 or calf thymus DNA. Dysplasia was detected in only one of these control animals. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carcinoma, Squamous Cell Microbiology DNA, Viral Genetics Genes, Viral Simplexvirus Uterine Cervical Dysplasia Uterine Cervical Neoplasms Animals Pathology Cell Line Isolation & Purification Mice Mice, Inbred C57BL Reference Values Pathogenicity Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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