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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Besemer, J. Muhm, M. Lechner, K. Bettelheim, P. Valent, P. Majdic, O. |
| Description | Author Affiliation: Valent P ( First Medical Department, University of Vienna, Austria.); |
| Abstract | Pure populations of human basophilic granulocytes were obtained from chronic myeloid leukemia (CML) blood by negative selection using a mixture of monoclonal antibodies and complement. 125I-radiolabeled recombinant human interleukin 3 (rhIL-3) bound to purified basophils in a specific manner. Quantitative binding studies and Scatchard plot analyses performed on samples from two donors revealed the presence of a single class of high-affinity IL-3 binding sites (500 and 2100 sites per cell; dissociation constant at equilibrium, 230 and 160 pmol/liter, respectively). Purified CML basophils maintained in suspension in the presence of rhIL-3 (100 units/ml) incorporated up to 12 times more [3H]thymidine than basophils in control cultures. Furthermore, after preincubation in vitro with rhIL-3 (100 units/ml) for 30 min, normal blood basophils released 2- to 3-fold more histamine than basophils pretreated with control medium when exposed to various concentrations of an anti-IgE antibody. Together, these results show that rhIL-3 binds to a specific receptor on blood basophils and is a regulator of basophil function. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Basophils Immunology Interleukin-3 Pharmacology Receptors, Immunologic Physiology Antibodies, Monoclonal Binding, Competitive Colony-Stimulating Factors DNA Replication Drug Effects Granulocyte-Macrophage Colony-Stimulating Factor Growth Substances Histamine Release In Vitro Techniques Interleukin-2 Metabolism Kinetics Receptors, Interleukin-3 Recombinant Proteins Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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