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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Acher, R. Chauvet, M. T. Chauvet, J. Rouillé, Y. Michel, G. |
| Description | Author Affiliation: Rouillé Y ( Laboratory of Biological Chemistry, University of Paris VI, France.); |
| Abstract | From neurointermediate pituitary glands of Xenopus laevis and Rana esculenta, previously unreported peptides termed hydrins, active on water permeability of frog urinary bladder and frog skin (Brunn or 'water-balance' effect), have been isolated and sequenced. These peptides seem to be derived from the pro-vasotocin-neurophysin precursor. Hydrin 1, found in Xenopus, has been identified as vasotocin C-terminally extended with the Gly-Lys-Arg sequence; hydrin 2, found in Rana, has been identified as vasotocin C-terminally extended with glycine. Hydrin 2 has been detected in several Ranidae (R. esculenta, Rana temporaria, Rana pipiens) and Bufonidae (Bufo bufo, Bufo ictericus) and appears to have a large distribution in terrestrial or semiaquatic anurans. Hydrins, in contrast to vasotocin, are not active on rat uterus or rat blood pressure. They are absent from other vasotocin-bearers such as birds and could be involved specifically in water-electrolyte regulation of amphibians. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Pituitary Gland, Posterior Physiology Vasotocin Analogs & Derivatives Genetics Acclimatization Amino Acid Sequence Animals Molecular Sequence Data Oxytocin Isolation & Purification Protein Processing, Post-Translational Rana Esculenta Species Specificity Water-Electrolyte Balance Xenopus Laevis Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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