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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Richter, D. Heierhorst, J. Lederis, K. Morley, S. D. Figueroa, J. Krentler, C. |
| Description | Author Affiliation: Heierhorst J ( Institut für Zellbiochemie und Klinische Neurobiologie, Universitäts-Krankenhaus Eppendorf, Hamburg, Federal Republic of Germany.); |
| Abstract | The nucleotide sequences of cloned cDNAs encoding the precursors for vasotocin and isotocin have been elucidated by analyzing a lambda gt11 library constructed from poly(A)+ RNA from the hypothalamic region of the teleost fish Catostomus commersoni. Screening of the library was carried out with synthetic oligonucleotide probes deduced from the amino acid sequences of the nonapeptides vasotocin and isotocin. The cDNA nucleotide sequences predict isotocin and vasotocin prohormone precursors each consisting of a signal peptide, a hormone moiety, and a neurophysin-like molecule. However, in comparison to their mammalian counterparts, both fish neurophysins are extended at their C termini by an approximately 30 amino acid sequence with a leucine-rich core segment. These extensions show striking similarities with the glycopeptide moiety (the so-called copeptin) present in mammalian vasopressin precursors, except that they lack the consensus sequence for N-glycosylation. These data suggest that mammalian copeptin is derived from the C terminus of an ancestral neurophysin. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 86 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1989-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cloning, Molecular DNA Genetics Oxytocin Analogs & Derivatives Protein Precursors Vasotocin Amino Acid Sequence Animals Arginine Vasopressin DNA-Directed DNA Polymerase Gene Amplification Genes Molecular Sequence Data Sequence Homology, Nucleic Acid Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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