NDLI: Ionizing radiation regulates expression of the c-jun protooncogene.

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Ionizing radiation regulates expression of the c-jun protooncogene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sherman, M. L. Datta, R. Hallahan, D. E. Weichselbaum, R. R. Kufe, D. W.
Description	Author Affiliation: Sherman ML ( Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Boston, MA.);
Abstract	There is little known about the regulation of gene expression by ionizing radiation exposure. The present studies demonstrate transcriptional activation of a mammalian gene, the c-jun protooncogene, by x-rays. The c-jun gene encodes a component of the AP-1 protein complex and is important in early signaling events involved in various cellular functions. The increase in c-jun transcripts by ionizing radiation was time- and dose-dependent as determined by Northern blot analysis. Transcriptional run-on analysis demonstrated that ionizing radiation stimulates the rate of c-jun gene transcription. Furthermore, the half-life of c-jun RNA was prolonged in the absence of protein synthesis. These findings indicate that the increase in c-jun RNA observed after irradiation is regulated by transcriptional and posttranscriptional mechanisms. Moreover, the induction of c-jun by ionizing radiation was associated with an inverse dose rate effect in that decreasing the dose rate resulted in increased c-jun expression. The present results similarly demonstrate that ionizing radiation increases levels of c-fos transcripts as well as that of jun-B, another member of the jun family. Taken together, these results suggest a role for induction of early response genes in the pathophysiologic effects of ionizing radiation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Genetics Gene Expression Regulation, Neoplastic Radiation Effects Proto-Oncogenes Transcription Factors Blotting, Northern Cell Line Cycloheximide Pharmacology Dose-Response Relationship, Radiation Protein Biosynthesis Drug Effects Proto-Oncogene Proteins Proto-Oncogene Proteins C-jun RNA, Neoplasm Isolation & Purification Transcription, Genetic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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