Loading...
Please wait, while we are loading the content...
Ionizing radiation regulates expression of the c-jun protooncogene.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sherman, Matthew L. Datta, R. P. Hallahan, Dennis E. Weichselbaum, Ralph R. Kufe, Donald |
| Copyright Year | 1990 |
| Abstract | There is little known about the regulation of gene expression by ionizing radiation exposure. The present studies demonstrate transcriptional activation of a mammalian gene, the c-jun protooncogene, by x-rays. The c-jun gene encodes a component of the AP-1 protein complex and is important in early signaling events involved in various cellular functions. The increase in c-jun transcripts by ionizing radiation was time- and dose-dependent as determined by Northern blot analysis. Transcriptional run-on analysis demonstrated that ionizing radiation stimulates the rate of c-jun gene transcription. Furthermore, the half-life of c-jun RNA was prolonged in the absence of protein synthesis. These findings indicate that the increase in c-jun RNA observed after irradiation is regulated by transcriptional and posttranscriptional mechanisms. Moreover, the induction of c-jun by ionizing radiation was associated with an inverse dose rate effect in that decreasing the dose rate resulted in increased c-jun expression. The present results similarly demonstrate that ionizing radiation increases levels of c-fos transcripts as well as that of jun-B, another member of the jun family. Taken together, these results suggest a role for induction of early response genes in the pathophysiologic effects of ionizing radiation. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/87/15/5663.full.pdf?origin=publication_detail |
| PubMed reference number | 2116003v1 |
| Volume Number | 87 |
| Issue Number | 15 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Exposure to radiation FOS gene Gene Expression Regulation Ionizing radiation JUN gene Mammals Proto-Oncogenes RNA Roentgen Rays Transcript Transcription, Genetic Transcriptional Activation |
| Content Type | Text |
| Resource Type | Article |
