NDLI: Folding and activity of hybrid sequence, disulfide-stabilized peptides.

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Folding and activity of hybrid sequence, disulfide-stabilized peptides.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pease, J. H. Storrs, R. W. Wemmer, D. E.
Description	Author Affiliation: Pease JH ( Department of Chemistry, University of California, Berkeley 94720.);
Abstract	Peptides have been synthesized that have hybrid sequences, partially derived from the bee venom peptide apamin and partially from the S peptide of ribonuclease A. The hybrid peptides were demonstrated by NMR spectroscopy to fold, forming the same disulfides and basic three-dimensional structure as native apamin, containing a beta-turn and an alpha-helix. These hybrids were active in complementing S protein, reactivating nuclease activity. In addition, the hybrid peptide was effective in inducing antibodies that cross-react with the RNase, without conjugation to a carrier protein. The stability of the folded structure of this peptide suggests that it should be possible to elicit antibodies that will react not only with a specific sequence, but also with a specific secondary structure. Hybrid sequence peptides also provide opportunities to study separately nucleation and propagation steps in formation of secondary structure. We show that in S peptide the alpha-helix does not end abruptly but rather terminates gradually over four or five residues. In general, these hybrid sequence peptides, which fold predictably because of disulfide bond formation, can provide opportunities for examining structure-function relationships for many biologically active sequences.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apamin Bee Venoms Peptides Protein Conformation Ribonuclease, Pancreatic Amino Acid Sequence Animals Disulfides Enzyme-Linked Immunosorbent Assay Immune Sera Macromolecular Substances Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Chemical Synthesis RNA, Ribosomal Metabolism Rabbits Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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