NDLI: Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

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Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

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Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Milich, D. R. Price, J. Jones, J. E. Mclachlan, A. Hughes, J. L. Raney, A. K.
Description	Author Affiliation: Milich DR ( Department of Molecular Biology, Scripps Clinic and Research Foundation, La Jolla 92037.);
Abstract	Infants born to hepatitis B virus carrier mothers, who express a secreted form of the nucleocapsid antigen designated HBeAg, invariably become persistently infected. To investigate the role of immunologic tolerance mechanisms in chronic infection of the newborn, we have generated HBeAg-expressing transgenic mice. HBeAg-expressing transgenic mice were tolerant to both HBeAg and the nonsecreted nucleocapsid (hepatitis B cor antigen/HBcAg) at the T-cell level. Transgenic mice did not produce antibody to HBeAg but did produce anti-HBc antibody in vivo and in vitro. The coexistence of tolerance to HBc/HBe T-cell determinants and anti-HBc antibody production in vivo parallels the immunologic status of neonates born to carrier mothers. It was also demonstrated that the maintenance of T-cell tolerance to HBcAg/HBeAg required the continued presence of the tolerogen and in its absence persisted for less than 16 weeks. The reversibility of T-cell tolerance to HBcAg/HBeAg may explain the inverse correlation between age of infection and rates of viral persistence. These observations suggest that a function of the HBeAg may be to induce immunologic tolerance in utero. Expression of HBeAg may represent a viral strategy to guarantee persistence after perinatal infection.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hepatitis B e Antigens Immunology Immune Tolerance T-Lymphocytes Animals Animals, Newborn Enzyme-Linked Immunosorbent Assay Hepatitis B Core Antigens Administration & Dosage Genetics Hepatitis B Virus Lymphocyte Activation Mice Mice, Transgenic Pregnancy Recombinant Proteins Restriction Mapping Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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