NDLI: Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1995 Volume: 92 Issue: 26

Year: 1995 Volume: 92 Issue: 25

Year: 1995 Volume: 92 Issue: 24

Year: 1995 Volume: 92 Issue: 23

Year: 1995 Volume: 92 Issue: 22

Year: 1995 Volume: 92 Issue: 21

Year: 1995 Volume: 92 Issue: 20

Year: 1995 Volume: 92 Issue: 19

Year: 1995 Volume: 92 Issue: 18

Year: 1995 Volume: 92 Issue: 17

Year: 1995 Volume: 92 Issue: 16

Year: 1995 Volume: 92 Issue: 15

Physics: the opening to complexity.

The physics and chemistry of heavy fermions.

New physics of metals: fermi surfaces without Fermi liquids.

The old problems of glass and the glass transition, and the many new twists.

Complexity, contingency, and criticality.

Scaling in geology: landforms and earthquakes.

Order and disorder in fluid motion.

Self-organized criticality: sandpiles, singularities, and scaling.

Inhibition of function in Xenopus oocytes of the inwardly rectifying G-protein-activated atrial K channel (GIRK1) by overexpression of a membrane-attached form of the C-terminal tail.

A potassium channel beta subunit related to the aldo-keto reductase superfamily is encoded by the Drosophila hyperkinetic locus.

Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display.

Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression.

Two cystic fibrosis transmembrane conductance regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents.

Identification of a retroviroid-like element from plants.

The tRNA processing enzyme RNase T is essential for maturation of 5S RNA.

Homologous recombination promoted by reverse transcriptase during copying of two distinct RNA templates.

Large secretory structures at the cell surface imaged with scanning force microscopy.

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers.

Binding studies of cationic thymidyl deoxyribonucleic guanidine to RNA homopolynucleotides.

Rapid local synchronization of action potentials: toward computation with coupled integrate-and-fire neurons.

Diffusion and formation of microtubule asters: physical processes versus biochemical regulation.

Genetic support for the out-of-Africa theory of human evolution.

Genetic absolute dating based on microsatellites and the origin of modern humans.

Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

Inhibitors of human heart chymase based on a peptide library.

An oleate 12-hydroxylase from Ricinus communis L. is a fatty acyl desaturase homolog.

Sex proportions of Haemoproteus blood parasites and local mate competition.

Cloning and expression of two brain-specific inwardly rectifying potassium channels.

Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop.

Stringent chemical and thermal regulation of recombinant gene expression by vaccinia virus vectors in mammalian cells.

Extrapituitary expression of the rat V1b vasopressin receptor gene.

Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis.

Considerations on the folding topology and evolutionary origin of cadherin domains.

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

Transition metal ion activation of DNA binding by the diphtheria tox repressor requires the formation of stable homodimers.

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.

Documentation of reticulate evolution in peonies (Paeonia) using internal transcribed spacer sequences of nuclear ribosomal DNA: implications for biogeography and concerted evolution.

Reproduction and sera embryotoxicity after immunization of monkeys with the laminin peptides YIGSR, RGD, and IKVAV.

A defective signal peptide in the maize high-lysine mutant floury 2.

Rescue of defective mitogenic signaling by D-type cyclins.

Augmented DNA-binding activity of p53 protein encoded by a carboxyl-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regularly spliced form.

Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice.

Limbic epilepsy in transgenic mice carrying a Ca2+/calmodulin-dependent kinase II alpha-subunit mutation.

On the existence and implications of an inverse folding code in proteins.

Multiple origins of the yucca-yucca moth association.

Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization.

Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.

Submillisecond folding of monomeric lambda repressor.

Trapping of branched DNA in microfabricated structures.

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease.

The kinetics of quantal transmitter release from retinal amacrine cells.

Expression of a flower-specific Myb protein in leaf cells using a viral vector causes ectopic activation of a target promoter.

Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner.

Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old).

STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.

Crystal and molecular structure of paclitaxel (taxol).

Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins.

Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.

Inactivation of simian immunodeficiency virus by hydrostatic pressure.

Amperometric detection of stimulus-induced quantal release of catecholamines from cultured superior cervical ganglion neurons.

Appearance of insulin-like growth factor mRNA in the liver and pyloric ceca of a teleost in response to exogenous growth hormone.

Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes.

Activin A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro.

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.

Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: 'positive' selection in appendix of normal and VH-mutant rabbits.

Expression of 5-lipoxygenase in differentiating human skin keratinocytes.

Preparation and properties of nido-carborane-specific monoclonal antibodies for potential use in boron neutron capture therapy for cancer.

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

The bacterial colicin active against tumor cells in vitro and in vivo is verotoxin 1.

Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.

Leukocytes express connexin 43 after activation with lipopolysaccharide and appear to form gap junctions with endothelial cells after ischemia-reperfusion.

De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells.

A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity.

Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains.

Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain.

Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila.

A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis.

Image processing via level set curvature flow.

Enhancer-dependent interaction between 5' and 3' splice sites in trans.

High-affinity binding sites for histone H1 in plasmid DNA.

Evidence that the 50-kDa substrate of brefeldin A-dependent ADP-ribosylation binds GTP and is modulated by the G-protein beta gamma subunit complex.

Dynamics of maize endosperm development and DNA endoreduplication.

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase.

Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39.

Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 92 Issue: 15)

Identification of a second homolog of N-ethylmaleimide-sensitive fusion protein that is expressed in the nervous system and secretory tissues of Drosophila.

Isolation of multiple sequences from the Plasmodium falciparum genome that encode conserved domains homologous to those in erythrocyte-binding proteins.

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

Mapping sites of interaction of p47-phox and flavocytochrome b with random-sequence peptide phage display libraries.

Convergent and parallel activation of low-conductance potassium channels by calcium and cAMP-dependent protein kinase.

Function of the p86 subunit of eukaryotic initiation factor (iso)4F as a microtubule-associated protein in plant cells.

Enhancers increase the probability but not the level of gene expression.

Genetic supercycles caused by cyclical selection.

Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 92 Issue: 15)

Year: 1995 Volume: 92 Issue: 14

Year: 1995 Volume: 92 Issue: 13

Year: 1995 Volume: 92 Issue: 12

Year: 1995 Volume: 92 Issue: 11

Year: 1995 Volume: 92 Issue: 10

Year: 1995 Volume: 92 Issue: 9

Year: 1995 Volume: 92 Issue: 8

Year: 1995 Volume: 92 Issue: 7

Year: 1995 Volume: 92 Issue: 6

Year: 1995 Volume: 92 Issue: 5

Year: 1995 Volume: 92 Issue: 4

Year: 1995 Volume: 92 Issue: 3

Year: 1995 Volume: 92 Issue: 2

Year: 1995 Volume: 92 Issue: 1

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Milich, D. R. Wolf, S. F. Jones, J. E. Hughes, J. L.
Description	Author Affiliation: Milich DR ( Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA.);
Abstract	Helper T (Th) cells are classified as Th1 or Th2 cells by virtue of cytokine secretion and function as mediators of cellular or humoral immunity, respectively. Cytokines also regulate the differentiation of Th cells. For example, interleukin (IL)-12 promotes Th1 and suppresses Th2 cell development, suggesting that IL-12 may be useful therapeutically in Th2-mediated autoimmune and allergic disorders. Therefore, the effect of systemic IL-12 treatment on in vivo autoantibody synthesis in hepatitis B e antigen (HBeAg)-expressing transgenic mice, which is dependent on self-reactive Th2 cells, was examined. Low-dose IL-12 significantly inhibited autoantibody production by shifting the Th2-mediated response toward Th1 predominance. Additionally, previous studies suggest that a predominance of HBeAg-specific Th2-type cells may contribute to chronicity in hepatitis B virus infection. Therefore, IL-12 may also prove beneficial in modulating the HBeAg-specific Th response to favor viral clearance in chronic hepatitis B virus infection.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoantibodies Biosynthesis Hepatitis B e Antigens Immunology Immunosuppression Interleukin-12 Pharmacology T-Lymphocytes, Helper-Inducer Animals Antibodies, Viral Autoimmune Diseases Therapy Cells, Cultured Cytokines Blood Genetics Immunoglobulin G Immunoglobulin Isotypes Immunotherapy, Adoptive Mice Mice, Transgenic Phenotype Recombinant Proteins Th1 Cells Th2 Cells Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in