NDLI: Role of 1,25-dihydroxycholecalciferol in growth-plate cartilage: inhibition of terminal differentiation of chondrocytes in vitro and in vivo.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1990 Volume: 87 Issue: 24

Year: 1990 Volume: 87 Issue: 23

Year: 1990 Volume: 87 Issue: 22

Year: 1990 Volume: 87 Issue: 21

Year: 1990 Volume: 87 Issue: 20

Year: 1990 Volume: 87 Issue: 19

Year: 1990 Volume: 87 Issue: 18

Year: 1990 Volume: 87 Issue: 17

Control of expression of Agrobacterium vir genes by synergistic actions of phenolic signal molecules and monosaccharides.

Metal-ion-center assembly of ferredoxin and plastocyanin in isolated chloroplasts.

Transformation of Halobacterium halobium: development of vectors and investigation of gas vesicle synthesis.

Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.

Interleukin 1 is an autocrine regulator of human endothelial cell growth.

Identification and characterization of the promoter for the cytotactin gene.

The spatial distribution of exposed nuclear DNA in normal, cancer, and reverse-transformed cells.

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

Molecular cloning of a gene encoding an ARS binding factor from the yeast Saccharomyces cerevisiae.

Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 87 Issue: 17)

Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alpha.

Interleukin 3 and granulocyte/macrophage-colony-stimulating factor render human basophils responsive to low concentrations of complement component C3a.

Hair-specific expression of chloramphenicol acetyltransferase in transgenic mice under the control of an ultra-high-sulfur keratin promoter.

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors.

Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia.

DNA polymerases alpha, delta, and epsilon: three distinct enzymes from HeLa cells.

Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

Prolactin effects on the dietary regulation of mouse mammary tumor virus proviral DNA expression.

Permeability of the murine blood-brain barrier to some octapeptide analogs of somatostatin.

RAP2B: a RAS-related GTP-binding protein from platelets.

Selective osmotic effect on diffusion of plasma membrane lipids in maize protoplasts.

Immunoglobulin heavy-chain-associated amyloidosis.

Evidence for a heat shock transcription factor-independent mechanism for heat shock induction of transcription in Saccharomyces cerevisiae.

General colorimetric method for DNA diagnostics allowing direct solid-phase genomic sequencing of the positive samples.

Detection of individual fluorescently labeled reovirions in living cells.

Genes for tryptophan biosynthesis in the archaebacterium Haloferax volcanii.

Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.

Sugars induce the Agrobacterium virulence genes through a periplasmic binding protein and a transmembrane signal protein.

Dysfunctional C1 inhibitor Ta: deletion of Lys-251 results in acquisition of an N-glycosylation site.

Use of brefeldin A to define sites of glycosphingolipid synthesis: GA2/GM2/GD2 synthase is trans to the brefeldin A block.

Rapid, sensitive analysis of protein mixtures by mass spectrometry.

Interphotoreceptor retinoid-binding protein promotes rhodopsin regeneration in toad photoreceptors.

Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum.

Internalization of vasopressin analogs in kidney and smooth muscle cells: evidence for receptor-mediated endocytosis in cells with V2 or V1 receptors.

A specific defect in CD3 gamma-chain gene transcription results in loss of T-cell receptor/CD3 expression late after human immunodeficiency virus infection of a CD4+ T-cell line.

Analytical determination of receptor-ligand dissociation constants of two populations of receptors from displacement curves.

Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation.

Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

In vitro assembly of relaxosomes at the transfer origin of plasmid RP4.

Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.

Biophysical model of a Hebbian synapse.

Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

Characterization of a beta subunit of the gastric H+/K(+)-transporting ATPase.

Changed distribution of sodium channels along demyelinated axons.

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

Pathway of proton transfer in bacterial reaction centers: replacement of serine-L223 by alanine inhibits electron and proton transfers associated with reduction of quinone to dihydroquinone.

Increased UV resistance in xeroderma pigmentosum group A cells after transformation with a human genomic DNA clone.

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.

Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats.

Diastereomer-dependent substrate reduction properties of a dinitrogenase containing 1-fluorohomocitrate in the iron-molybdenum cofactor.

Inter- and intraspecies spread of Escherichia coli in a farm environment in the absence of antibiotic usage.

Cloning by function: an alternative approach for identifying yeast homologs of genes from other organisms.

Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

Substrate specificity of trypsin investigated by using a genetic selection.

Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae.

Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase in mammalian cells.

Cloning and cDNA sequence of a bovine submaxillary gland mucin-like protein containing two distinct domains.

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.

Secretion and cell surface expression of IgG1 are impaired in human B lymphoblasts that lack HLA-A, -B, and -C antigens. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 87 Issue: 17)

Molecular genetics of X chromosome-linked color vision among populations of African and Japanese ancestry: high frequency of a shortened red pigment gene among Afro-Americans.

Role of 1,25-dihydroxycholecalciferol in growth-plate cartilage: inhibition of terminal differentiation of chondrocytes in vitro and in vivo.

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

Interleukin 2 receptor beta chain expressed in an oligodendroglioma line binds interleukin 2 and delivers growth signal.

Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid plexus.

Gene activation is required for developmentally programmed cell death.

Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

Peripheral tolerance in mice expressing a liver-specific class I molecule: inactivation/deletion of a T-cell subpopulation.

Purification of two transcription factors required for initiation by mammalian RNA polymerase II.

Fluorescence in situ hybridization with Alu and L1 polymerase chain reaction probes for rapid characterization of human chromosomes in hybrid cell lines.

Simultaneous localization of cosmids and chromosome R-banding by fluorescence microscopy: application to regional mapping of human chromosome 11.

Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.

Characterization of a fibrillar collagen gene in sponges reveals the early evolutionary appearance of two collagen gene families.

Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).

Molecular phylogeny of Rodentia, Lagomorpha, Primates, Artiodactyla, and Carnivora and molecular clocks.

Processing of prosecretin: isolation of a secretin precursor from porcine intestine.

Prevention of spontaneous and radiation-induced tumors in rats by reduction of food intake.

Sensitization of bleached rod photoreceptors by 11-cis-locked analogues of retinal.

Inhibition of Na-K-C1 cotransport in Ehrlich ascites cells by antiserum against purified proteins of the cotransporter.

Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens.

A major endothelial plasmalemmal sialoglycoprotein, gp60, is immunologically related to glycophorin.

Expression of the maize Cat3 catalase gene is under the influence of a circadian rhythm.

Isolation of carp genes encoding major histocompatibility complex antigens.

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

Molecular structure of leucine aminopeptidase at 2.7-A resolution.

Inhibition of estrogen receptor-DNA binding by the 'pure' antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

Polarized integrin mediates human keratinocyte adhesion to basal lamina.

Lipid domains in the ram sperm plasma membrane demonstrated by differential scanning calorimetry.

Casein expression in cytotoxic T lymphocytes.

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells.

Isolation and characterization of a cDNA clone for the Cat2 gene in maize and its homology with other catalases. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 87 Issue: 17)

Year: 1990 Volume: 87 Issue: 16

Year: 1990 Volume: 87 Issue: 15

Year: 1990 Volume: 87 Issue: 14

Year: 1990 Volume: 87 Issue: 13

Year: 1990 Volume: 87 Issue: 12

Year: 1990 Volume: 87 Issue: 11

Year: 1990 Volume: 87 Issue: 10

Year: 1990 Volume: 87 Issue: 9

Year: 1990 Volume: 87 Issue: 8

Year: 1990 Volume: 87 Issue: 7

Year: 1990 Volume: 87 Issue: 6

Year: 1990 Volume: 87 Issue: 5

Year: 1990 Volume: 87 Issue: 4

Year: 1990 Volume: 87 Issue: 3

Year: 1990 Volume: 87 Issue: 2

Year: 1990 Volume: 87 Issue: 1

Year: 1990 Volume: 87 Issue: Suppl

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Role of 1,25-dihydroxycholecalciferol in growth-plate cartilage: inhibition of terminal differentiation of chondrocytes in vitro and in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sato, K. Nishii, Y. Suzuki, F. Shimazu, A. Iwamoto, M. Koike, T. Kato, Y. Nakashima, K.
Description	Author Affiliation: Kato Y ( Department of Biochemistry, Faculty of Dentistry, Osaka University, Japan.);
Abstract	The effects of vitamin D metabolites on alkaline phosphatase [ALPase; orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] activity, a marker of terminal differentiation, in chondrocyte cultures and growth plates in vivo were examined. In cultures of pelleted rabbit growth-plate chondrocytes, 1,25-dihydroxycholecalciferol (1,25-dihydroxyvitamin D3) increased the contents of DNA and macromolecules containing uronic acid (proteoglycans). It also decreased ALPase activity with an ED50 of less than 1 nM. Other vitamin D3 metabolites, such as 24,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol, had little effect on these biochemical parameters. In rachitic growth plates, the uronic acid content was half that in normal growth plates, whereas ALPase activity was 2.5 times that in normal growth plates. Administration of 1,25-dihydroxycholecalciferol at a low dose (0.1 micrograms per kg of body weight) to rachitic rats increased the uronic acid content 1.4-fold and decreased ALPase activity by 40%. This compound, like 24,25-dihydroxycholecalciferol (10 micrograms per kg of body weight), increased the calcium level of the blood. However, administration of 24,25-dihydroxycholecalciferol had little effect on the uronic acid and ALPase contents in growth plates. These observations suggest that 1,25-dihydroxycholecalciferol is a bioactive form of vitamin D that plays an important role in the control of chondrocyte terminal differentiation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcitriol Pharmacology Cell Differentiation Drug Effects Growth Plate Cytology 24,25-Dihydroxyvitamin D 3 Alkaline Phosphatase Metabolism Animals Calcium Blood DNA Replication Enzymology Phosphates Rabbits Reference Values Rickets Pathology Uronic Acids Vitamin D Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in