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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, T. Matsunaga, T. Törmänen, V. |
| Description | Author Affiliation: Matsunaga T ( Unit for Applied Cell and Molecular Biology, University of Umea, Sweden.); |
| Abstract | A germ-line heavy-chain variable region (VH) gene (RTVH431) has been isolated from a rainbow trout (Salmo gairdneri) and characterized by complete nucleotide sequencing. It is characteristic of VH, as shown by the conserved octamer and TATA motif in the 5' region, the heptamernonamer recombination signal sequence in the 3' region, and the 18-amino-acid-long hydrophobic leader interrupted by an intron. The 98-amino-acid-long VH coding region has 50-70% nucleotide sequence homology and 40-60% amino acid sequence homology with VHS of various vertebrate species. We have also found unique or species-specific amino acid residues in the VHS of rainbow trout, amphibia (Xenopus), reptile (Caiman), and shark (Heterodontus) in our sequence analyses. The RTVH431 has an unusual amino acid in the conserved 34th position in complementarity-determining region 1 of VH. Southern hybridization results suggest the presence of a large gene family related to RTVH431 in the trout genome. The complex evolution of antibody V genes is discussed. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 19 |
| Volume Number | 87 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1990-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genes, Immunoglobulin Immunoglobulin Heavy Chains Genetics Immunoglobulin Variable Region Trout Immunology Amino Acid Sequence Animals Blotting, Southern Cloning, Molecular DNA Isolation & Purification Genomic Library Molecular Sequence Data Nucleic Acid Hybridization Restriction Mapping Sequence Homology, Nucleic Acid Testis Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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