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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Takahashi, Y. Le Douarin, N. |
| Description | Author Affiliation: Takahashi Y ( Institut d'Embryologie du Centre National de la Recherche Scientifique, Collège de France, Nogent-sur-Marne.); |
| Abstract | We report here the cloning of a quail cDNA related to the Drosophila gene msh and to the mouse genes Hox-7 and Hox-7.1. For this reason we called this cDNA Quox-7. The amino acid homology of Quox-7 cDNA with the above mentioned genes is high (83%) for the homeobox and its 5'- and 3'-flanking sequences, and the homology is medium (43%) for another stretch of amino acids upstream of the homeobox; elsewhere the sequences of quail and mouse cDNAs have diverged significantly. In quail embryos of day 2-5, Quox-7 transcripts were found essentially in the ventral mesenchyme (neural crest-derived mesectoderm of the face and hypobranchial structures, somatopleure, and limbs) and also in a narrow dorsomedial band of cells of the superficial ectoderm and neural tube. This pattern is fundamentally similar to that reported for Hox-7/7.1, suggesting that the products of these genes play a similar role in the development of the different classes of vertebrates. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 19 |
| Volume Number | 87 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1990-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DNA Genetics Genes, Homeobox Mesoderm Physiology Neural Crest Amino Acid Sequence Animals Cloning, Molecular Connective Tissue Isolation & Purification Embryo, Nonmammalian Molecular Sequence Data Quail RNA Probes Restriction Mapping Sequence Homology, Nucleic Acid Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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