NDLI: In vivo channeling of substrates in an enzyme aggregate for beta-carotene biosynthesis.

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In vivo channeling of substrates in an enzyme aggregate for beta-carotene biosynthesis.

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Two-dimensional life?

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In vivo channeling of substrates in an enzyme aggregate for beta-carotene biosynthesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Candau, R. Cerdá-olmedo, E. Bejarano, E. R.
Description	Author Affiliation: Candau R ( Departamento de Genética y Biotecnia, Facultad de Biología, Universidad de Sevilla, Spain.);
Abstract	The existence and the mode of operation of certain enzyme aggregates may be established from the concentrations of intermediates measured in the presence of specific inhibitors. beta-Carotene, the most abundant carotenoid pigment in the fungus Phycomyces blakesleeanus, arises from ring formation at both ends of lycopene. The inhibitors nicotine, imidazole, alpha-picoline, and 2-(4-chlorophenylthio)triethylamine lead to the simultaneous accumulation of lycopene, beta-carotene, and the one-ring intermediate gamma-carotene. The quantitative analytical values obey precise mathematical relationships: those expected from the operation of an enzyme aggregate with two cyclases equally sensitive to the inhibitors. The intermediates lycopene and gamma-carotene rejected by chemically inhibited enzymes may be readmitted to other cyclases in the wild type but not in heterokaryons containing a carA mutation. We have calculated the fraction of inhibited cyclase under each condition, the affinity constant of each inhibitor for the cyclase, and the probability that a rejected intermediate molecule will be readmitted and further metabolized. The probabilities for lycopene and gamma-carotene are identical and independent of the inhibitor responsible for the rejection. Our calculations suggest that each rejected intermediate molecule is readmitted to the enzyme aggregates two or three times on the average.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carotenoids Biosynthesis Multienzyme Complexes Metabolism Phycomyces Enzymology Ethylamines Pharmacology Imidazoles Kinetics Models, Theoretical Nicotine Drug Effects Picolines Beta Carotene Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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