NDLI: Single amino acid substitutions in the cAMP receptor protein specifically abolish regulation by the CytR repressor in Escherichia coli.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1991 Volume: 88 Issue: 24

Year: 1991 Volume: 88 Issue: 23

Year: 1991 Volume: 88 Issue: 22

Year: 1991 Volume: 88 Issue: 21

Year: 1991 Volume: 88 Issue: 20

Year: 1991 Volume: 88 Issue: 19

Year: 1991 Volume: 88 Issue: 18

Year: 1991 Volume: 88 Issue: 17

Year: 1991 Volume: 88 Issue: 16

Year: 1991 Volume: 88 Issue: 15

Year: 1991 Volume: 88 Issue: 14

Year: 1991 Volume: 88 Issue: 13

Year: 1991 Volume: 88 Issue: 12

Year: 1991 Volume: 88 Issue: 11

Localization of xanthine dehydrogenase in cowpea root nodules: implications for the interaction between cellular compartments during ureide biogenesis.

Chlororespiration: an adaptation to nitrogen deficiency in Chlamydomonas reinhardtii.

Regulation of movement speed by intracellular pH during Dictyostelium discoideum chemotaxis.

Structural femtochemistry: experimental methodology.

Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold.

The MCK enhancer contains a p53 responsive element.

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells.

The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo.

Cardiac reperfusion damage prevented by a nitroxide free radical.

A covalent complex between retroviral integrase and nicked substrate DNA.

Alternative translocation of protons and halide ions by bacteriorhodopsin.

Autophosphorylation of type II Ca2+/calmodulin-dependent protein kinase in cultures of postnatal rat hippocampal slices.

Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells.

Deletion of sequences upstream of the proteinase improves the proteolytic processing of human immunodeficiency virus type 1.

Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5.

Use of a rapid, efficient inoculation method to induce papillomas by cottontail rabbit papillomavirus DNA shows that the E7 gene is required.

Evidence for retrotransposition of the I factor, a LINE element of Drosophila melanogaster.

Structure-function relationships of the mouse inositol 1,4,5-trisphosphate receptor.

Single amino acid substitutions in the cAMP receptor protein specifically abolish regulation by the CytR repressor in Escherichia coli.

From one gene to two proteins: the biogenesis of cytochromes b and c1 in Bradyrhizobium japonicum.

cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.

Nitric oxide: an endogenous modulator of leukocyte adhesion.

Polymorphism in purified guanylate cyclase from vertebrate rod photoreceptors.

Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

Linkage mapping of the human CSF2 and IL3 genes.

2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin.

Cloning and expression of the human vasoactive intestinal peptide receptor.

Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris.

Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells.

Enzyme activities in four different forms of human immunodeficiency virus 1 pol gene products.

Cytolytic and ion channel-forming properties of the N terminus of lymphocyte perforin.

Computation of ionic distributions around charged biomolecular structures: results for right-handed and left-handed DNA.

Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions.

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

Characterization of the decay-accelerating factor gene promoter region.

Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients.

Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules.

Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor.

Epitope mapping by mutagenesis distinguishes between the two tertiary structures of the histidine-containing protein HPr.

Characterization of a member of the immunoglobulin gene superfamily that possibly represents an additional class of growth factor receptor.

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo.

Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 88 Issue: 11)

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.

Purification of murine suppressive factor of allergy into distinct CD23-modulating and IgE-suppressive proteins.

Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.

Influence of the cardiac myosin hinge region on contractile activity.

Kinesin is responsible for centrifugal movement of pigment granules in melanophores.

An additional function for bacteriophage lambda rex: the rexB product prevents degradation of the lambda O protein.

Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.

Photosynthetic electron transport controls nitrogen assimilation in cyanobacteria by means of posttranslational modification of the glnB gene product.

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants.

Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus.

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.

Immunogenicity of an engineered internal image antibody.

Bispecific antibodies that mediate killing of cells infected with human immunodeficiency virus of any strain.

Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.

Production of a monocot-specific monoclonal antibody against acetohydroxyacid synthase and its use in the purification and characterization of the enzyme.

Alternatively spliced products of the maize P gene encode proteins with homology to the DNA-binding domain of myb-like transcription factors.

Inactivation of the Zfx gene on the mouse X chromosome.

DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae.

Infection by mink cell focus-forming viruses confers interleukin 2 (IL-2) independence to an IL-2-dependent rat T-cell lymphoma line.

Immunization of simian immunodeficiency virus-infected rhesus monkeys with soluble human CD4 elicits an antiviral response.

Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor.

Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects.

Kinetics of antigenic peptide binding to the class II major histocompatibility molecule I-Ad.

Transmembrane domain length variation in the evolution of major histocompatibility complex class I genes.

Characterization of posttranslational modifications in neuron-specific class III beta-tubulin by mass spectrometry.

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

Targeted inactivation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination.

Zone-specific regulation of two messenger RNAs for P450c11 in the adrenals of pregnant and nonpregnant rats.

Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation.

Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease.

Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.

Chloroquine inhibits heme-dependent protein synthesis in Plasmodium falciparum.

Centrioles in the beginning of human development.

Selective activation of human heat shock gene transcription by nitrosourea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor.

Unusual isomeric polyunsaturated fatty acids in liver phospholipids of rats fed hydrogenated oil.

Deficiency of essential fatty acids and membrane fluidity during pregnancy and lactation.

Organization of the gene for human erythrocyte membrane protein 4.2: structural similarities with the gene for the a subunit of factor XIII.

Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.

Genetic basis of X-Y chromosome dissociation and male sterility in interspecific hybrids.

A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of alpha-LCAT activity.

Mixed nicotinic and muscarinic features of cholinergic receptor coupled to secretion in bovine chromaffin cells.

Mitochondrial respiration in hummingbird flight muscles.

Fundamental theorem of natural selection under gene-culture transmission.

Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia.

Isolation of TFC1, a gene encoding one of two DNA-binding subunits of yeast transcription factor tau (TFIIIC).

The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions.

Suppression of phase separation in solutions of bovine gamma IV-crystallin by polar modification of the sulfur-containing amino acids.

Cytosolic Ca2+ deregulation and blebbing after HgCl2 injury to cultured rabbit proximal tubule cells as determined by digital imaging microscopy.

Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein.

In vivo channeling of substrates in an enzyme aggregate for beta-carotene biosynthesis.

Iron-independent induction of ferritin H chain by tumor necrosis factor.

Where practice makes perfect in texture discrimination: evidence for primary visual cortex plasticity.

Innervation and neural regulation of the sex pheromone gland in female Heliothis moths.

Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.

Channeling of aminoacyl-tRNA for protein synthesis in vivo.

Genetic basis for p53 overexpression in human breast cancer.

Microtubule destabilization and neurofilament phosphorylation precede dendritic sprouting after close axotomy of lamprey central neurons.

Microtubule mediation of cytoplasmic and nuclear maturation during the early stages of resumed meiosis in cultured mouse oocytes.

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

Year: 1991 Volume: 88 Issue: 10

Year: 1991 Volume: 88 Issue: 9

Year: 1991 Volume: 88 Issue: 8

Year: 1991 Volume: 88 Issue: 7

Year: 1991 Volume: 88 Issue: 6

Year: 1991 Volume: 88 Issue: 5

Year: 1991 Volume: 88 Issue: 4

Year: 1991 Volume: 88 Issue: 3

Year: 1991 Volume: 88 Issue: 2

Year: 1991 Volume: 88 Issue: 1

Two-dimensional life?

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Single amino acid substitutions in the cAMP receptor protein specifically abolish regulation by the CytR repressor in Escherichia coli.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Søgaard-andersen, L. Mironov, A. S. Valentin-hansen, P. Pedersen, H. Sukhodelets, V. V.
Description	Author Affiliation: Søgaard-Andersen L ( Department of Molecular Biology, Odense University, Denmark.);
Abstract	Promoters in Escherichia coli that are negatively regulated by the CytR repressor are also activated by the cAMP receptor protein (CRP) complexed to cAMP; as a characteristic, these promoters encode tandem binding sites for cAMP-CRP. In one such promoter, deoP2, CytR binds to the region between the tandem CRP binding sites with a relatively low affinity; in the presence of cAMP-CRP, however, the repressor and activator bind cooperatively to the DNA. Here we have investigated this cooperativity by isolating mutants of the CRP protein that abolish CytR regulation without exhibiting a concomitant loss in their ability to activate transcription. Four different, single amino acid substitutions in CRP give rise to this phenotype. These amino acids lie in close proximity on the surface of the CRP tertiary structure in a portion of the protein that is not in contact with the DNA. In vitro analyses of one of the CRP mutants show that it interacts with the DNA in a manner indistinguishable from wild-type CRP, whereas its interaction with CytR is perturbed. These results strongly indicate that cooperative DNA binding of CytR and cAMP-CRP is achieved through protein-protein interactions.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacterial Proteins Metabolism Cyclic AMP Receptor Protein Escherichia Coli Repressor Proteins Cloning, Molecular Genetics Deoxyribonuclease I Escherichia Coli Proteins Macromolecular Substances Models, Molecular Mutagenesis, Site-Directed Plasmids Promoter Regions, Genetic Protein Binding Protein Conformation Recombinant Proteins Beta-Galactosidase Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in