NDLI: Unusual isomeric polyunsaturated fatty acids in liver phospholipids of rats fed hydrogenated oil.

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Unusual isomeric polyunsaturated fatty acids in liver phospholipids of rats fed hydrogenated oil.

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Unusual isomeric polyunsaturated fatty acids in liver phospholipids of rats fed hydrogenated oil.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Svingen, B. Pusch, F. Holman, R. T. Dutton, H. J.
Description	Author Affiliation: Holman RT ( Hormel Institute, University of Minnesota, Austin 55912.);
Abstract	Linoleic acid (18:2 omega 6) and linolenic acid (18:3 omega 3) are precursors of two series of essential fatty acids (EFA) formed by alternate desaturations and elongations. In EFA deficiency (EFAD), oleic acid (18:1 omega 9) and palmitoleic acid (16:1 omega 7) undergo the same reactions to form polyunsaturated fatty acids (PUFA) of other structures. Partially hydrogenated soybean oil (PHSO) contains isomeric 18:1 acids that can be converted to unusual isomers of 18:2 by liver microsomes. To test whether 18:2, 20:3, and 20:4 of unusual structure occur in phospholipids as a consequence of EFAD or ingestion of PHSO, rats were fed corn oil, an EFA-deficient diet, or PHSO to provide isomeric 18:1 acids. At 2.5 months the phospholipids were isolated from livers and converted to methyl esters, and the 18:2, 20:2, 20:3, and 20:4 fractions were isolated. The 18:2 and 20:2 fractions were ozonized, and, by using a computer solution of simultaneous equations, the structures and proportions of each isomer were calculated. The 20:3 and 20:4 fractions were analyzed by ozonolysis and capillary gas chromatography. When corn oil was fed, the major isomer in each group was 9,12-18:2, 11,14-20:2, 8,11,14-20:3, and 5,8,11,14-20:4. Patterns in EFAD- and PHSO-fed groups were more diverse, with large proportions of unusual isomers. Feeding EFA-deficient diet and PHSO induced measurable amounts of unusual PUFA at each step of the cascade, and these PUFA may compete in metabolism of normal PUFA and are substrates for oxidative formation of autacoids of unknown structures and function.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dietary Fats Pharmacology Fatty Acids, Nonesterified Liver Metabolism Phospholipids Plant Oils Animals Chromatography, Gas Corn Oil Fatty Acids, Essential Deficiency Isomerism Drug Effects Isolation & Purification Rats, Inbred Strains Reference Values Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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