NDLI: Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

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Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

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Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bose, H. R. Verma, I. M. Inoue, J. Kerr, L. D. Rashid, D. Davis, N.
Description	Author Affiliation: Inoue J ( Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92186-5800.);
Abstract	To understand the mechanism by which pp40/I kappa B beta inhibits DNA binding activity of the rel/NF-kappa B family of transcription factors, we have investigated the role of ankyrin repeats on the biological function of pp40 by deleting or mutating conserved residues. We show that (i) ankyrin repeats alone are not sufficient to manifest biological activity but require the C-terminal region of the pp40 protein; (ii) four out of the five ankyrin repeats are essential for inhibiting the DNA binding activity; (iii) pp40 mutants that do not inhibit DNA binding of rel protein also do not associate with rel; (iv) although pp40 can associate with the p65 and p50 subunits of NF-kappa B, pp40 inhibits the DNA binding activity of only the p50-p65 heterodimer and the p65 homodimer; and (v) pp40 inhibits the transcription of genes linked to kappa B site; however, mutants that do not affect DNA binding have no effect. We propose that the ankyrin repeats and the C-terminal region of pp40 form a structure that associates with the rel homology domain to inhibit DNA binding activity.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Proteins Genetics DNA Metabolism Membrane Proteins NF-kappa B Phosphoproteins Proto-Oncogene Proteins Retroviridae Proteins, Oncogenic Transcription Factors Amino Acid Sequence Animals Ankyrins Cell Line Kinetics Molecular Sequence Data Mutagenesis, Site-Directed Oligodeoxyribonucleotides Oncogene Proteins V-rel Protein Biosynthesis Proto-Oncogene Proteins C-rel Repetitive Sequences, Nucleic Acid Restriction Mapping Transcription Factor RelB Transfection Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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