NDLI: Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.

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Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Soldatov, N. M.
Description	Author Affiliation: Soldatov NM ( Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021-6399.);
Abstract	The nucleotide sequence of cDNA encoding the human fibroblast Ca2+ channel of L type (HFCC) has been determined. It is highly homologous to L-type channels previously cloned from rabbit lung and heart as well as from rat brain. At least four sites of molecular diversity were identified in the nucleotide sequence of HFCC. Three of these include regions encoding the transmembrane segments IIS6, IIIS2, and IVS3, which are known to be important for channel gating properties. The positions of these sites correlate with RNA splice sites, indicating that the molecular diversity of the transcripts is a result of alternative splicing. The fourth diversity region is located at the C-terminal region and comprises insertions and deletions. It is suggested that these variations may give rise to multiple subforms of HFCC with altered electrophysiological properties.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Channels Genetics Genetic Variation Transcription, Genetic Amino Acid Sequence Cell Line Cell Membrane Metabolism Cloning, Molecular DNA Isolation & Purification DNA Probes Exons Fibroblasts Physiology Gene Library Introns Molecular Sequence Data Oligodeoxyribonucleotides Oligonucleotides, Antisense Polymerase Chain Reaction Protein Conformation Sequence Homology, Nucleic Acid Skin Physiological Phenomena Comparative Study Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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