NDLI: Induction of tolerance to an IgG autoantibody.

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Induction of tolerance to an IgG autoantibody.

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Induction of tolerance to an IgG autoantibody.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Factor, S. Offen, D. Escowitz, H. Spatz, L. Diamond, B.
Description	Author Affiliation: Offen D ( Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461.);
Abstract	Nonautoimmune mice transgenic for the heavy chain of an IgG2b anti-double-stranded-DNA antibody express the transgene in lymphoid organs and display partial allelic exclusion of this gamma 2b transgene. The spleens of these mice are characterized by marked B-cell depletion. Although there are B cells in these mice that express the transgene and recognize double-stranded DNA, they are anergic in vivo. Recovery from the state of anergy occurs in vitro after lipopolysaccharide stimulation. Thus this transgenic model demonstrates the induction of self tolerance to an IgG autoantibody.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Antinuclear Genetics Immune Tolerance Immunoglobulin G Animals Immunology B-Lymphocytes Gene Expression Genes Kidney Pathology Lipopolysaccharides Mice Mice, Transgenic RNA, Messenger Spleen Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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