NDLI: Homology of a vesicular amine transporter to a gene conferring resistance to 1-methyl-4-phenylpyridinium.

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Homology of a vesicular amine transporter to a gene conferring resistance to 1-methyl-4-phenylpyridinium.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stern-bach, Y. Findlay, J. B. Keen, J. N. Wallach, M. Bejerano, M. Steiner-mordoch, S. Schuldiner, S.
Description	Author Affiliation: Stern-Bach Y ( Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Israel.);
Abstract	The vesicular amine transporter (VAT) catalyzes transport and storage of catechol and indolamines into subcellular organelles in a wide variety of cells. It plays a central role in neurotransmission and is the primary target for several pharmacological agents. One of the drugs, reserpine, binds very tightly to the transporter and remains bound even after solubilization, a finding that has proven useful for purification of the transporter from bovine adrenal medulla in a fully functional state. The sequences of 26 N-terminal amino acids and of an additional 7-amino acid internal peptide are presented. Antibodies against a synthetic peptide based on the above sequences immunoprecipitate the transporter, confirming the conclusion that the peptide sequence is derived from bovine VAT. To our knowledge, documentation of sequences of vesicular neurotransmitter transporters has not been presented previously. In addition, the sequences obtained are highly homologous to the predicted sequence of a protein from PC12 cells that confers to Chinese hamster ovary cells resistance to 1-methyl-4-phenylpyridinium (MPP+), an agent that causes parkinsonism in model systems, confirming the hypothesis that the protein conferring resistance to MPP+ is a VAT.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	1-Methyl-4-phenylpyridinium Pharmacology Glycoproteins Metabolism Membrane Glycoproteins Membrane Transport Proteins Neuropeptides Neurotransmitter Agents Adrenal Glands Chemistry Amines Amino Acid Sequence Animals Biological Transport Drug Resistance Molecular Sequence Data Peptides Immunology Precipitin Tests Sequence Alignment Synaptic Vesicles Vesicular Biogenic Amine Transport Proteins Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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