NDLI: Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1992 Volume: 89 Issue: 24

Year: 1992 Volume: 89 Issue: 23

Year: 1992 Volume: 89 Issue: 22

Year: 1992 Volume: 89 Issue: 21

Year: 1992 Volume: 89 Issue: 20

Foraging ability of rufous hummingbirds on hummingbird flowers and hawkmoth flowers.

Rainbow trout chimeras produced by injection of blastomeres into recipient blastulae.

Configurations of adsorbed hard spheres after diffusion in a gravitational field.

Asexual metazoans undergo senescence.

A 5' to 3' exonuclease functionally interacts with calf DNA polymerase epsilon.

Hypoxia and N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate, but not nerve growth factor, induce Na+ channels and hypertrophy in chromaffin-like arterial chemoreceptors.

Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor.

Origins of genes: 'big bang' or continuous creation?

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

Genetic predisposition of transgenic mouse melanocytes to melanoma results in malignant melanoma after exposure to a low ultraviolet B intensity nontumorigenic for normal melanocytes.

Characterization of muscarinic receptor subtypes inhibiting Ca2+ current and M current in rat sympathetic neurons.

Large and small vertebrate sensory neurons express different Na and K channel subtypes.

Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas.

Evidence for the role of dendritic spines in the temporal filtering properties of neurons: the decoding problem and beyond.

Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity.

Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1.

Competitive adsorption of human immunoglobulin G and albumin: consequences for structure and reactivity of the adsorbed layer.

A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.

RNA binding determinant in some class I tRNA synthetases identified by alignment-guided mutagenesis.

Instability of assembled T-cell receptor complex that is associated with rapid degradation of zeta chains in immature CD4+CD8+ thymocytes.

Regulation of recombinant rat tyrosine hydroxylase by dopamine.

Somatostatin receptors are expressed by immature cerebellar granule cells: evidence for a direct inhibitory effect of somatostatin on neuroblast activity.

Transfer and expression of the human multiple drug resistance gene into live mice.

Homology of a vesicular amine transporter to a gene conferring resistance to 1-methyl-4-phenylpyridinium.

Cloning and expression of chicken erythrocyte transglutaminase.

Cloning, genetic mapping, and expression analysis of an Arabidopsis thaliana gene that encodes 1-aminocyclopropane-1-carboxylate synthase.

A phylogenetic analysis of the myxobacteria: basis for their classification.

Radioprotection of mice by recombinant rat stem cell factor.

High-resolution mapping of mammalian genes by in situ hybridization to free chromatin.

Association of protein-tyrosine kinase with phospholipase C-gamma 1 in bone marrow-derived mouse mast cells.

Direct analysis of the binding of Src-homology 2 domains of phospholipase C to the activated epidermal growth factor receptor.

A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.

Reverse transcriptase of human immunodeficiency virus can use either human tRNA(3Lys) or Escherichia coli tRNA(2Gln) as a primer in an in vitro primer-utilization assay.

Regulation of the reverse transcriptase of human immunodeficiency virus type 1 by dNTPs.

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

Antirepression function in Escherichia coli for the cAMP-cAMP receptor protein transcriptional activator.

Kinetic role of nonnative species in the folding of bovine pancreatic trypsin inhibitor.

Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes.

Peptoids: a modular approach to drug discovery.

Cloning and chromosomal mapping of a human immunodeficiency virus 1 'TATA' element modulatory factor.

Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.

Both purified human 1,N6-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N6-ethenoadenine and 3-methyladenine.

Spontaneous insertion of polypeptide chains into membranes: a Monte Carlo model.

Activation of potassium channels: relationship to the heat shock response.

Grammatical model of the regulation of gene expression.

Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.

Complementation of a red-light-indifferent cyanobacterial mutant.

Role of the basic amino acid cluster and Glu-23 in pyrimidine dimer glycosylase activity of T4 endonuclease V.

Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody.

Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of human immunodeficiency virus type 1.

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.

Cell cycle-dependent localization of casein kinase I to mitotic spindles.

Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus aureus plasmid pI258.

Regulation of the yeast DNA replication genes through the Mlu I cell cycle box is dependent on SWI6.

The repressor MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences.

Retroviral analysis of cardiac morphogenesis: discontinuous formation of coronary vessels.

Primary electron transfer kinetics in bacterial reaction centers with modified bacteriochlorophylls at the monomeric sites BA,B.

Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules.

Birth and migration of neurons in the central posterior/prepacemaker nucleus during adulthood in weakly electric knifefish (Eigenmannia sp.).

Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study.

Farnesylcysteine, a constituent of the alpha and beta subunits of rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometry.

Characterization of the genes encoding phycoerythrin in the red alga Rhodella violacea: evidence for a splitting of the rpeB gene by an intron.

Structure of the host-specific toxins produced by the fungal pathogen Periconia circinata.

Initiation of phi 29 DNA replication occurs at the second 3' nucleotide of the linear template: a sliding-back mechanism for protein-primed DNA replication.

Imaging of luciferase secretion from transformed Chinese hamster ovary cells.

Reductive detoxification as a mechanism of fungal resistance to singlet oxygen-generating photosensitizers.

Mutational analysis of the integrase protein of human immunodeficiency virus type 2.

1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain.

Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages.

Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells.

Scanning tunneling microscopy imaging of Torpedo acetylcholine receptor.

Detection of transcripts for the receptor for macrophage colony-stimulating factor, c-fms, in murine osteoclasts.

Symmetry in the mechanism of bacteriophage lambda integrative recombination.

Plasmodium chabaudi p68 serine protease activity required for merozoite entry into mouse erythrocytes.

Distinct binding sites on HLA-DR for invariant chain and staphylococcal enterotoxins.

Dendritic field size and morphology of midget and parasol ganglion cells of the human retina.

Quinolone binding to DNA is mediated by magnesium ions.

Conformational substates in azurin.

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

Direct stimulation of immediate-early genes by intranuclear insulin in trypsin-treated H35 hepatoma cells.

Myristoylation of the G alpha i2 polypeptide, a G protein alpha subunit, is required for its signaling and transformation functions.

Allosteric changes in the cAMP receptor protein of Escherichia coli: hinge reorientation.

Isolation of DNA sequences deleted in lung cancer by genomic difference cloning.

Selective expression of human X chromosome-linked green opsin genes.

Asn177 in Escherichia coli thymidylate synthase is a major determinant of pyrimidine specificity.

Circular dichroism and molecular modeling yield a structure for the complex of human immunodeficiency virus type 1 trans-activation response RNA and the binding region of Tat, the trans-acting transcriptional activator.

Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion.

Trisomy 7 and trisomy 10 characterize subpopulations of tumor-infiltrating lymphocytes in kidney tumors and in the surrounding kidney tissue.

Recombinant antibody-metallothionein: design and evaluation for radioimmunoimaging.

Metal-binding chimeric antibodies expressed in Escherichia coli.

A broad molecular phylogeny of ciliates: identification of major evolutionary trends and radiations within the phylum.

Molecular phylogenetic inference from saber-toothed cat fossils of Rancho La Brea.

Genetic analysis of the interaction between bacteriophage T7 DNA polymerase and Escherichia coli thioredoxin.

Establishment of a highly sensitive and specific exon-trapping system.

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

Purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from apple fruit.

The path of carbon in photosynthesis: improved crop yields with methanol.

Second-site revertants of an arginine-210 to lysine mutation in the a subunit of the F0F1-ATPase from Escherichia coli: implications for structure.

Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.

Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts.

Isolation and sequence of a cDNA encoding the precursor of a bombesinlike peptide from brain and early embryos of Xenopus laevis.

Ligation-anchored PCR: a simple amplification technique with single-sided specificity.

Growth hormone induces multiplication of the slowly cycling germinal cells of the rat tibial growth plate.

Roles of selection and recombination in the evolution of type I restriction-modification systems in enterobacteria.

Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes.

von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.

Membrane and synaptic properties of developing lateral geniculate nucleus neurons during retinogeniculate axon segregation.

Growing tips of type I collagen fibrils formed in vitro are near-paraboloidal in shape, implying a reciprocal relationship between accretion and diameter.

Helical model of nucleation and propagation to account for the growth of type I collagen fibrils from symmetrical pointed tips: a special example of self-assembly of rod-like monomers.

Genetically engineered rice resistant to rice stripe virus, an insect-transmitted virus.

Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator.

A 105-kDa protein is required for yeast mitochondrial RNase P activity.

A protein methyltransferase specific for altered aspartyl residues is important in Escherichia coli stationary-phase survival and heat-shock resistance.

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia.

Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia.

Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene.

A phorbol ester response element within the human T-cell receptor beta-chain enhancer.

Selective disruption of growth hormone transcription machinery by viral infection.

Leishmania infections damage the feeding mechanism of the sandfly vector and implement parasite transmission by bite.

Progesterone modulates a neuronal nicotinic acetylcholine receptor.

Paradoxical increase in striatal neuropeptide gene expression following ischemic lesions of the cerebral cortex.

Unsaturation of fatty acids in membrane lipids enhances tolerance of the cyanobacterium Synechocystis PCC6803 to low-temperature photoinhibition.

Year: 1992 Volume: 89 Issue: 19

Year: 1992 Volume: 89 Issue: 18

Year: 1992 Volume: 89 Issue: 17

Year: 1992 Volume: 89 Issue: 16

Year: 1992 Volume: 89 Issue: 15

Year: 1992 Volume: 89 Issue: 14

Year: 1992 Volume: 89 Issue: 13

Year: 1992 Volume: 89 Issue: 12

Year: 1992 Volume: 89 Issue: 11

Year: 1992 Volume: 89 Issue: 10

Year: 1992 Volume: 89 Issue: 9

Year: 1992 Volume: 89 Issue: 8

Year: 1992 Volume: 89 Issue: 7

Year: 1992 Volume: 89 Issue: 6

Year: 1992 Volume: 89 Issue: 5

Year: 1992 Volume: 89 Issue: 4

Year: 1992 Volume: 89 Issue: 3

Year: 1992 Volume: 89 Issue: 2

Year: 1992 Volume: 89 Issue: 1

On the nature of global classification.

Theory of hydrophobicity: transient cavities in molecular liquids.

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Harrison, L. C. De Aizpurua, H. J. Wilson, Y. M.
Description	Author Affiliation: De Aizpurua HJ ( Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.);
Abstract	Insulin-dependent diabetes mellitus (IDDM) is associated with serum antibodies that precipitate a 64-kDa pancreatic islet cell protein reported to be glutamic acid decarboxylase (GAD; glutamate decarboxylase, EC 4.1.1.15). Previously, antibodies to GAD were found in the rare neurological disorder stiff man syndrome. To demonstrate directly antibodies to GAD, enzymatically active GAD was first purified from fresh human cerebellum. Brain GAD activity was precipitated by noninhibitory antibodies in the sera of 16/26 (62%) subjects defined as having preclinical IDDM (islet cell antibody-positive first-degree relatives of a person with IDDM), 3/13 (23%) with recent-onset IDDM, and 3/3 with the stiff man syndrome. In addition, sera of 5/26 (19%) preclinical and 2/13 (15%) recent-onset IDDM subjects contained antibodies that precipitated GAD but inhibited its activity. Thus, overall, 21/26 (81%) preclinical and 5/13 (38%) recent-onset IDDM subjects had antibodies that precipitated GAD activity. Antibodies to GAD were not detected in sera from subjects with other autoimmune diseases (n = 29) or healthy controls (n = 14). GAD affinity-purified to homogeneity (specific activity, 58 units/mg) was specifically immunoprecipitated as a single 60-kDa species by the IDDM sera. In an ELISA incorporating whole mouse brain GAD captured by the GAD-6 monoclonal antibody the frequencies of GAD antibodies for all subject groups were indistinguishable from those found by precipitation of human brain enzymatic activity. We conclude that (i) GAD is an (auto)antigen in a majority of subjects operationally defined as having preclinical IDDM, (ii) pancreatic islet and brain GAD are likely to be cross-reactive, and (iii) the majority of GAD antibodies are directed away from the catalytic site of the brain enzyme. The lower frequency of GAD antibodies in recent-onset IDDM subjects indicates either that immunoreactivity is lost with near-total beta-cell destruction or that GAD antibodies denote a low risk of progression to clinical disease.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoantibodies Immunology Diabetes Mellitus, Type 1 Glutamate Decarboxylase Adolescent Brain Enzymology Chromatography, Affinity Isolation & Purification Metabolism Precipitin Tests Substrate Specificity Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in