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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Meyhöfer, E. Howard, J. |
| Description | Author Affiliation: Meyhöfer E ( Department of Physiology and Biophysics, University of Washington, Seattle 98195.); |
| Abstract | To probe the mechanism by which the motor protein kinesin moves along microtubules, we have developed a highly sensitive technique for measuring the force exerted by a single motor molecule. In this technique, one end of a microtubule is attached to the tip of a flexible glass fiber of calibrated stiffness. The other end of the microtubule makes contact with a surface sparsely coated with kinesin. By imaging the tip of the glass fiber on a photodiode detector, displacement of the microtubule by kinesin through as little as 1 nm can be detected and forces as small as 1 pN resolved. Using this force-fiber apparatus we have characterized the mechanical output of this molecular motor. The speed at which a molecule of kinesin moved along the surface of a microtubule decreased linearly as the elastic force was increased. The force required to stop a single kinesin molecule was 5.4 +/- 1.0 pN (mean +/- SD; n = 16), independent of the stiffness of the fiber, the damping from the fluid, and whether the ATP concentration was high or low. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 92 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1995-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Kinesin Physiology Microtubules Adenosine Triphosphate Metabolism Animals Biomechanical Phenomena Biophysics Instrumentation Brain Chemistry Elasticity Electric Conductivity Movement Pressure Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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