NDLI: Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival.

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Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival.

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Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sitar, K. L. Disbrow, G. L. Frelinger, J. G. Dragone, L. L. Barth, R. K.
Description	Author Affiliation: Dragone LL ( Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642.);
Abstract	Leukosialin (also known as Ly48, CD43, and sialophorin) is a major cell surface sialoglycoprotein found on a variety of hematopoietically derived cells. The precise function of this molecule is poorly understood but it has been implicated in cell proliferation and intercellular adhesion. We developed a transgenic mouse model to assess leukosialin's function in vivo. Our approach was to alter mouse CD43 (mCD43) expression in the B-cell lineage where it is tightly regulated, by expressing it in peripheral B cells where it is normally absent. To drive expression of leukosialin in mature B cells, the immunoglobulin heavy chain enhancer was fused to the mCD43 gene. mCD43-immunoglobulin heavy chain enhancer transgenic mice display splenomegaly due to increased numbers of B cells. Transgenic B cells show a striking increase in their ability to survive in vitro compared to B cells from nontransgenic control mice. This prolonged survival is reflected in a decreased susceptibility to apoptosis. These observations suggest that mCD43 plays an important role in the regulation of B-cell survival. The alteration of the temporal expression, or 'disregulation,' of a gene in transgenic mice provides a general strategy for elucidating the in vivo role of other molecules involved in cell signaling and adhesion.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, CD B-Lymphocytes Immunology Gene Expression Regulation Hematopoietic Stem Cells Sialoglycoproteins Biosynthesis Spleen Animals Antigens, CD43 Apoptosis Cell Count Cell Differentiation Cell Survival Enhancer Elements, Genetic Genetics Flow Cytometry Mice Mice, Transgenic Recombinant Fusion Proteins Cytology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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