NDLI: Position-dependent variegation of globin transgene expression in mice.

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Position-dependent variegation of globin transgene expression in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Garrick, D. Wu, W. Robertson, G. Martin, D. Whitelaw, E. Kearns, M.
Description	Author Affiliation: Robertson G ( Department of Biochemistry, University of Sydney, New South Wales, Australia.);
Abstract	Expression of genes in eukaryotes has commonly been analyzed in a whole tissue, and levels of expression have been interpreted as the result of equivalent rates of transcription in every cell. We have produced transgenic mouse lines that express beta-galactosidase under the control of globin promoters linked to the major tissue-specific regulatory element of the alpha-globin locus, which permits the analysis of transgene expression in individual red blood cells. We find that expression of the transgene within all mouse lines is heterocellular. Individual cells either do not express the transgene at all or express it at a level characteristic of that line. The number of beta-galactosidase-expressing cells varies greatly between different lines of transgenic mice at any defined stage of development, but within a transgenic line, individual mice have strikingly similar numbers of expressing cells. This suggests that the degree of heterocellular expression is determined by the site of integration, as is seen in position-effect variegation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Globins Genetics Animals Lac Operon Mice Mice, Transgenic Promoter Regions, Genetic Beta-Galactosidase Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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