NDLI: Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A.

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Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hu, M. K. Malkovsky, M. Bartz, S. R. Hohenwalter, E. Rich, D. H.
Description	Author Affiliation: Bartz SR ( Department of Medical Microbiology and Immunology, University of Wisconsin, Madison 53706, USA.);
Abstract	Analogs of the immunosuppressive cyclic undecapeptide cyclosporin A (CsA) with substitutions in positions 1, 4, 6, and/or 11 were rationally designed to possess substantially diminished or no immunosuppressive activity. When these compounds were assayed for their capacity to interfere with the replication of human immunodeficiency virus, some displayed a potent antiviral activity in newly infected cells. However, only CsA could interfere with virus replication in persistently infected cells. One CsA analog with antiviral activity costimulated the phytohemagglutinin-induced production of interleukin 2 by human lymphocytes. Human immunodeficiency virus particles from drug-exposed cells showed lower infectivity than virions from untreated cells. Thus, these nonimmunosuppressive analogs of CsA constitute a promising class of lead compounds to develop drugs for effective treatment of the acquired immunodeficiency syndrome.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antiviral Agents Pharmacology Cyclosporins HIV Drug Effects Virus Replication Cell Line Cyclosporine Chemistry Drug Design Pathogenicity Physiology Interleukin-2 Biosynthesis Lymphocyte Activation Lymphocytes Immunology Models, Molecular Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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