NDLI: Ascorbic acid is essential for the release of insulin from scorbutic guinea pig pancreatic islets.

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Ascorbic acid is essential for the release of insulin from scorbutic guinea pig pancreatic islets.

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Ascorbic acid is essential for the release of insulin from scorbutic guinea pig pancreatic islets.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dou, C. Z. Kalbach, H. L. Xu, D. P. Jung, C. H. Wells, W. W. Dybas, L. N.
Description	Author Affiliation: Wells WW ( Department of Biochemistry, Michigan State University, East Lansing 48824, USA.);
Abstract	Pancreatic islets from young normal and scorbutic male guinea pigs were examined for their ability to release insulin when stimulated with elevated D-glucose. Islets from normal guinea pigs released insulin in a D-glucose-dependent manner showing a rapid initial secretion phase and three secondary secretion waves during a 120-min period. Islets from scorbutic guinea pigs failed to release insulin during the immediate period, and only delayed and decreased responses were observed over the 40-60 min after D-glucose elevation. Insulin release from scorbutic islets was greatly elevated if 5 mM L-ascorbic acid 2-phosphate was supplemented in the perifusion medium during the last 60 min of perifusion. When 5 mM L-ascorbic acid 2-phosphate was added to the perifusion medium concurrently with elevation of medium D-glucose, islets from scorbutic guinea pigs released insulin as rapidly as control guinea pig islets and to a somewhat greater extent. L-Ascorbic acid 2-phosphate without elevated D-glucose had no effect on insulin release by islets from normal or scorbutic guinea pigs. The pancreas from scorbutic guinea pigs contained 2.4 times more insulin than that from control guinea pigs, suggesting that the decreased insulin release from the scorbutic islets was not due to decreased insulin synthesis but due to abnormal insulin secretion.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Ascorbic Acid Deficiency Metabolism Ascorbic Acid Analogs & Derivatives Glucose Pharmacology Insulin Secretion Islets Of Langerhans Animals Biological Transport Glutathione Glutathione Disulfide Guinea Pigs In Vitro Techniques Drug Effects Ultrastructure Perfusion Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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