NDLI: An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor.

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Quasars and active galactic nuclei: high resolution radio imaging.

Very-long-baseline radio interferometry surveys of the compact structure in active galactic nuclei.

Morphology of high-luminosity compact radio sources.

Very-long-baseline radio interferometry observations of low power radio galaxies.

Structure and evolution of the compact radio source in NGC 1275.

The parsec-scale jet in M87.

Subparsec-scale structure and evolution of Centaurus A (NGC5128).

The nuclear jet and counterjet region of the radio galaxy Cygnus A.

The nuclear region of the spiral galaxy M81.

Very-long-baseline radio interferometry (VLBI) observations of gamma-ray blazars: results from millimeter-VLBI observations.

Bidirectional motion observed in the compact symmetric object 1946+708.

Superluminal sources.

Grs 1915+105: a superluminal source in the Galaxy.

Possible links between BL Lacertae objects and quasars from very long baseline interferometry radio data.

The case for unification.

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Unification and large-scale structure.

Compact steep-spectrum sources and the unified scheme.

Optical evidence for the unification of active galactic nuclei and quasi-stellar objects.

Probing active galactic nuclei with H2O megamasers.

Gravitational lensing of active galactic nuclei.

Probes of the inner jets of blazars.

The acceleration and collimation of jets.

Evolution of powerful extragalactic radio sources.

Lipoxygenase-catalyzed oxygenation of storage lipids is implicated in lipid mobilization during germination.

Plant histochemistry by correlation peak imaging.

Radial versus tangential migration of neuronal clones in the developing cerebral cortex.

The histone fold: evolutionary questions.

Uniparental inheritance of mitochondrial and chloroplast genes: mechanisms and evolution.

Sequence verification of human creatine kinase (43 kDa) isozymes by high-resolution tandem mass spectrometry. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 92 Issue: 25)

Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.

In vitro trans-splicing in Saccharomyces cerevisiae.

A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.

Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea.

Identification of a Drosophila G protein alpha subunit (dGq alpha-3) expressed in chemosensory cells and central neurons.

Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage.

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.

A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.

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Isolation of virus-neutralizing RNAs from a large pool of random sequences.

Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

Proton transport by a bacteriorhodopsin mutant, aspartic acid-85-->asparagine, initiated in the unprotonated Schiff base state.

An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor.

Induction of a Cryphonectria parasitica cellobiohydrolase I gene is suppressed by hypovirus infection and regulated by a GTP-binding-protein-linked signaling pathway involved in fungal pathogenesis.

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An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Amrein, H. Hedley, M. L. Maniatis, T.
Description	Author Affiliation: Hedley ML ( Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.);
Abstract	We have identified an amino acid sequence in the Drosophila Transformer (Tra) protein that is capable of directing a heterologous protein to nuclear speckles, regions of the nucleus previously shown to contain high concentrations of spliceosomal small nuclear RNAs and splicing factors. This sequence contains a nucleoplasmin-like bipartite nuclear localization signal (NLS) and a repeating arginine/serine (RS) dipeptide sequence adjacent to a short stretch of basic amino acids. Sequence comparisons from a number of other splicing factors that colocalize to nuclear speckles reveal the presence of one or more copies of this motif. We propose a two-step subnuclear localization mechanism for splicing factors. The first step is transport across the nuclear envelope via the nucleoplasmin-like NLS, while the second step is association with components in the speckled domain via the RS dipeptide sequence.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Compartmentation Cell Nucleus Metabolism Drosophila Proteins Nuclear Proteins RNA Splicing Amino Acid Sequence Animals Ultrastructure Cells, Cultured Cloning, Molecular Fluorescent Antibody Technique Genes, Myc HeLa Cells Molecular Sequence Data Genetics Peptides Ribonucleoproteins Serine-Arginine Splicing Factors Structure-Activity Relationship Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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