NDLI: B cells are not essential for peripheral T-cell tolerance.

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B cells are not essential for peripheral T-cell tolerance.

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B cells are not essential for peripheral T-cell tolerance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Scherer, M. T. Schultz, L. Kappler, J. W. Vella, A. T. Marrack, P.
Description	Author Affiliation: Vella AT ( Howard Hughes Medical Institute, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.);
Abstract	Some self-reactive T cells avoid thymic tolerance and become mature peripheral cells. Nevertheless, these cells do not usually attack their hosts because T cells can be inactivated or killed, even after they are mature, by various means. The details of these processes are not fully understood; however, a number of experiments have suggested that peripheral tolerance may be induced in mature mouse T cells by exposure to antigen on resting B cells, cells that can express antigen bound to major histocompatibility complex proteins but that lack critical costimulatory molecules such as B7-1 and B7-2. Conversely, previous experiments have indicated that mature T cells can be stimulated by exposure to antigen on cells such as dendritic cells, cells that are thought to express the essential costimulatory molecules. We tested this idea in vivo by using mice that lack B cells. Unexpectedly, T-cell tolerance and antigen-induced T-cell death occurred normally in mice free of B cells. On the other hand, antigen-specific T-cell expansion in the spleens of such mice was impaired. Finally, we have recently shown that T-cell death in mice can be prevented by exposure to antigen and an inflammatory agent such as bacterial lipopolysaccharide. This was also true in mice that lacked B cells. Overall, these data show that mature T cells can be tolerized and rescued from tolerance in the absence of B cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Immunology Immune Tolerance T-Lymphocytes Animals Cell Death Clonal Deletion Cytochrome c Group Enterotoxins Immunization Lymph Nodes Cytology Lymphocyte Activation Mice Mice, Mutant Strains Models, Immunological Receptors, Antigen, T-Cell, Alpha-beta Genetics Self Tolerance Spleen Superantigens Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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