NDLI: The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.

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The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Martinez-climent, J. A. Dreyling, M. H. Rowley, J. D. Bohlander, S. K. Mao, J. Zheng, M.
Description	Author Affiliation: Dreyling MH ( Section of Hematology/Oncology, University of Chicago, IL 60637, USA.);
Abstract	The translocation t(10;11)(p13;q14) is a recurring chromosomal abnormality that has been observed in patients with acute lymphoblastic leukemia as well as acute myeloid leukemia. We have recently reported that the monocytic cell line U937 has a t(10;11)(p13;q14) translocation. Using a combination of positional cloning and candidate gene approach, we cloned the breakpoint and were able to show that AF10 is fused to a novel gene that we named CALM (Clathrin Assembly Lymphoid Myeloid leukemia gene) located at 11q14. AF10, a putative transcription factor, had recently been cloned as one of the fusion partners of MLL. CALM has a very high homology in its N-terminal third to the murine ap-3 gene which is one of the clathrin assembly proteins. The N-terminal region of ap-3 has been shown to bind to clathrin and to have a high-affinity binding site for phosphoinositols. The identification of the CALM/AF10 fusion gene in the widely used U937 cell line will contribute to our understanding of the malignant phenotype of this line.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromosomes, Human, Pair 10 Genetics Chromosomes, Human, Pair 11 Monomeric Clathrin Assembly Proteins Translocation, Genetic Adaptor Proteins, Vesicular Transport Amino Acid Sequence Animals Cell Line Cloning, Molecular DNA Primers DNA, Complementary In Situ Hybridization, Fluorescence Leukemia, Myeloid, Acute Mice Molecular Sequence Data Monocytes Ultrastructure Nerve Tissue Proteins Phosphoproteins Sequence Homology, Amino Acid Transcription Factors Tumor Cells, Cultured Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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