NDLI: Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha.

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Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha.

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Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Johnson, E. M. Chepenik, L. G. Khalili, K. Krachmarov, C. P. Barr-vagell, S.
Description	Author Affiliation: Krachmarov CP ( Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.);
Abstract	JC virus is activated to replicate in glial cells of many AIDS patients with neurological disorders. In human glial cells, the human immunodeficiency virus 1 (HIV-1) Tat protein activates the major late promoter of JC virus through a Tat-responsive DNA element, termed upTAR, which is a recognition site for cellular Pur alpha, a sequence-specific single-stranded DNA binding protein implicated in cell cycle control of DNA replication and transcription. Tat interacts with two leucine-rich repeats in Pur alpha to form a complex that can be immunoprecipitated from cell extracts. Tat enhances the ability of purified glutathione S-transferase-Pur alpha (GST-Pur alpha) to bind the upTAR element. Tat acts synergistically with Pur alpha, in a cell-cycle-dependent manner, to activate transcription at an upTAR element placed upstream of a heterologous promoter. Since Pur alpha is ubiquitously expressed in human cells and since PUR elements are located near many promoters and origins of replication, the Tat-Pur alpha interaction may be implicated in effects of HIV-1 throughout the full range of HIV-1-infected cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cyclic AMP Response Element-Binding Protein DNA-Binding Proteins Metabolism Gene Products, Tat HIV-1 Physiology JC Virus Neuroglia Virology Transcription, Genetic Virus Activation Virus Replication Amino Acid Sequence Binding Sites Cell Cycle Cell Line Chloramphenicol O-Acetyltransferase Biosynthesis DNA Replication Chemistry Isolation & Purification Glioblastoma Leucine Molecular Sequence Data Protein Binding Recombinant Proteins Sequence Deletion Sequence Homology, Amino Acid Transcription Factors Transfection Tat Gene Products, Human Immunodeficiency Virus Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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