NDLI: Fork-like DNA templates support bypass replication of lesions that block DNA synthesis on single-stranded templates.

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Fork-like DNA templates support bypass replication of lesions that block DNA synthesis on single-stranded templates.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Burnouf, D. Pillaire, M. J. Fuchs, R. P. Hoffmann, J. S. Defais, M. Lesca, C. Villani, G.
Description	Author Affiliation: Hoffmann JS ( Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Unité Propre de Recherche 9062, Toulouse, France.);
Abstract	DNA replication is an asymmetric process involving concurrent DNA synthesis on leading and lagging strands. Leading strand synthesis proceeds concomitantly with fork opening, whereas synthesis of the lagging strand essentially takes place on a single-stranded template. The effect of this duality on DNA damage processing by the cellular replication machinery was tested using eukaryotic cell extracts and model DNA substrates containing site-specific DNA adducts formed by the anticancer drug cisplatin or by the carcinogen N-2-acetylaminofluorene. Bypass of both lesions was observed only with fork-like substrates, whereas complete inhibition of DNA synthesis occurred on damaged single-stranded DNA substrates. These results suggest a role for additional accessory factors that permit DNA polymerases to bypass lesions when present in fork-like DNA.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Adducts DNA Damage DNA Replication DNA, Single-Stranded Chemistry Metabolism Nucleic Acid Conformation 2-Acetylaminofluorene Animals Antineoplastic Agents CHO Cells Carcinogens Cisplatin Cricetinae Isolation & Purification Molecular Sequence Data Templates, Genetic Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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