NDLI: The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1996 Volume: 93 Issue: 26

Year: 1996 Volume: 93 Issue: 25

Year: 1996 Volume: 93 Issue: 24

Time-resolved optical diffusion tomographic image reconstruction in highly scattering turbid media.

Effects of productivity, consumers, competitors, and El Niño events on food chain patterns in a rocky intertidal community.

Distinct roles for two G protein alpha subunits in fungal virulence, morphology, and reproduction revealed by targeted gene disruption.

Arabidopsis thaliana defense-related protein ELI3 is an aromatic alcohol:NADP+ oxidoreductase.

Memory: recording experience in cells and circuits: diversity in memory research.

Memory systems in the brain and localization of a memory.

Toward a molecular definition of long-term memory storage.

A synaptic basis for memory storage in the cerebral cortex.

Discovery of genes involved with learning and memory: an experimental synthesis of Hirschian and Benzerian perspectives.

The fractionation of working memory.

Regional and cellular fractionation of working memory.

Memory from the dynamics of intrinsic membrane currents.

Ensemble codes involving hippocampal neurons are at risk during delayed performance tests.

Neural mechanisms for visual memory and their role in attention.

Functional organization of the hippocampal memory system.

Involvement of the amygdala in memory storage: interaction with other brain systems.

Structure and function of declarative and nondeclarative memory systems.

Studies of retrograde memory: a long-term view.

Illusory memories: a cognitive neuroscience analysis.

Memory systems analyses of mnemonic disorders in aging and age-related diseases.

Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease.

Cognitive and neurobiologic markers of early Alzheimer disease.

Twinkle, twinkle little StAR, how we wonder what you are.

Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists.

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal.

YY1 transcriptional initiator: protein interactions and association with a DNA site containing unpaired strands.

Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator.

A small engineered protein lacks structural uniqueness by increasing the side-chain conformational entropy.

Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.

Evidence for a transcriptional activation function of BRCA1 C-terminal region.

Sucrose biosynthesis in a prokaryotic organism: Presence of two sucrose-phosphate synthases in Anabaena with remarkable differences compared with the plant enzymes

The role of apolipoprotein AI domains in lipid binding.

Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100.

Chemical nature of the light emitter of the Aequorea green fluorescent protein.

PCR-based development of DNA substrates containing modified bases: an efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins.

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.

Superoxide accelerates DNA damage by elevating free-iron levels

The essential yeast RNA binding protein Np13p is methylated.

Gly-63-->Gln substitution adjacent to His-64 in rodent carbonic anhydrase IVs largely explains their reduced activity.

Pepsin-inhibitory activity of the uterine serpins.

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity.

Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds.

A critical arginine residue mediates cooperativity in the contact interface between transcription factors NFAT and AP-1.

Fidelity of RNA polymerase II transcription controlled by elongation factor TFIIS.

A peroxidase related to the mammalian antimicrobial protein myeloperoxidase in the Euprymna-Vibrio mutualism.

Elimination of the Chlamydomonas gene family that encodes the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase

A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa S6 kinase gene

The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex

In vitro activation of Stat3 by epidermal growth factor receptor kinase

Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.

Melanotropic peptide-conjugated beads for microscopic visualization and characterization of melanoma melanotropin receptors.

A cytokine mRNA-destabilizing element that is structurally and functionally distinct from A+U-rich elements.

Defective subunit assembly underlies a digenic form of retinitis pigmentosa linked to mutations in peripherin/rds and rom-1.

Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action.

An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5' cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site.

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome.

Metal binding properties and secondary structure of the zinc-binding domain of Nup475

The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo.

Fork-like DNA templates support bypass replication of lesions that block DNA synthesis on single-stranded templates.

Characterization of individual polynucleotide molecules using a membrane channel.

Ultrafast exciton relaxation in the B850 antenna complex of Rhodobacter sphaeroides.

TOR2 is required for organization of the actin cytoskeleton in yeast.

Inhibition of interleukin 1 beta-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP.

Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo.

Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate.

The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.

Calexcitin: A signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes.

Multiple A-type cyclins express sequentially during the cell cycle in Nicotiana tabacum BY2 cells.

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

Flowers into shoots: photo and hormonal control of a meristem identity switch in Arabidopsis.

Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans.

Blockade of plasma membrane calcium pumping ATPase isoform I impairs nerve growth factor-induced neurite extension in pheochromocytoma cells

Developmental expression of synthetic cis-regulatory systems composed of spatial control elements from two different genes.

Misconceptions about mitochondria and mammalian fertilization: implications for theories on human evolution.

Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction.

The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney.

The structural H19 gene is required for transgene imprinting.

Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can functionas an enhancer element in Drosophila

A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene.

A positive genetic selection for disrupting protein-protein interactions: identification of CREB mutations that prevent association with the coactivator CBP.

Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase.

A procedure for the prediction of temperature-sensitive mutants of a globular protein based solely on the amino acid sequence.

An upstream activator of transcription coordinately increases the level and epigenetic stability of gene expression.

Transcription-induced mutations: increase in C to T mutations in the nontranscribed strand during transcription in Escherichia coli.

Highly selective isolation of human DNAs from rodent-human hybrid cells as circular yeast artificial chromosomes by transformation-associated recombination cloning.

Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma.

Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast.

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development.

Lack of chromosome territoriality in yeast: promiscuous rejoining of broken chromosome ends.

myb provides an essential function during Drosophila development.

Absence of the β subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the $α_{1}$ subunit and eliminates excitation-contraction coupling

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.

Role of p300-family proteins in E1A oncogene induction of cytolytic susceptibility and tumor cell rejection.

The mouse mammary tumor virus env gene is the source of a CD8+ T-cell-stimulating peptide presented by a major histocompatibility complex class I molecule in a murine thymoma.

Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin-class I-TAP complexes.

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

In vitro V(D)J recombination: signal joint formation.

A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.

In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain.

Frequent clones of p53-mutated keratinocytes in normal human skin.

Biochemical characterization and intracellular localization of the Menkes disease protein.

Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential.

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.

Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation.

Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 93 Issue: 24)

The AML1/ETO fusion protein activates transcription of BCL-2.

Brain monoamine oxidase A inhibition in cigarette smokers.

Efficient gene transfer by a human immunodeficiency virus type 1 (HIV-1)-derived vector utilizing a stable HIV packaging cell line.

HIV replication in CD4+ T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous beta-chemokines and the viral inductive effects of other endogenous cytokines.

Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein.

Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway.

Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males.

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha.

Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice.

Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat.

Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal gamma-aminobutyric acid transmission in the conscious rat.

Transcriptional control of circadian hormone synthesis via the CREM feedback loop.

Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative $Ca^{2+} entry$

Embryonic neuronal markers in tuberous sclerosis: single-cell molecular pathology.

Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys.

Brain drug delivery of small molecules using immunoliposomes.

Interactions between two divalent ion binding sites in N-methyl-D-aspartate receptor channels.

Transgenic mice carrying the dominant rhodopsin mutation P347S: Evidence for defective vectorial transport of rhodopsin to the outer segments

Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia.

Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants.

Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying $K^{+}$ channel subunit

Identification of proton-active residues in a higher plant light-harvesting complex.

A conserved repetitive DNA element located in the centromeres of cereal chromosomes.

Year: 1996 Volume: 93 Issue: 23

Year: 1996 Volume: 93 Issue: 22

Year: 1996 Volume: 93 Issue: 21

Year: 1996 Volume: 93 Issue: 20

Year: 1996 Volume: 93 Issue: 19

Year: 1996 Volume: 93 Issue: 18

Year: 1996 Volume: 93 Issue: 17

Year: 1996 Volume: 93 Issue: 16

Year: 1996 Volume: 93 Issue: 15

Year: 1996 Volume: 93 Issue: 14

Year: 1996 Volume: 93 Issue: 13

Year: 1996 Volume: 93 Issue: 12

Year: 1996 Volume: 93 Issue: 11

Year: 1996 Volume: 93 Issue: 10

Year: 1996 Volume: 93 Issue: 9

Year: 1996 Volume: 93 Issue: 8

Year: 1996 Volume: 93 Issue: 7

Year: 1996 Volume: 93 Issue: 6

Year: 1996 Volume: 93 Issue: 5

Year: 1996 Volume: 93 Issue: 4

Year: 1996 Volume: 93 Issue: 3

Year: 1996 Volume: 93 Issue: 2

Year: 1996 Volume: 93 Issue: 1

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sands, A. T. Donehower, L. A. Jones, S. N. Bradley, A. Linke, S. P. Wahl, G. M. Hancock, A. R. Vogel, H.
Description	Author Affiliation: Jones SN ( Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.);
Abstract	The Mdm2 oncoprotein forms a complex with the p53 tumor suppressor protein and inhibits p53-mediated regulation of heterologous gene expression. Recently, Mdm2 has been found to bind several other proteins that function to regulate cell cycle progression, including the E2F-1/DP1 transcription factor complex and the retinoblastoma tumor-suppressor protein. To determine whether Mdm2 plays a role in cell cycle control or tumorigenesis that is distinct from its ability to modulate p53 function, we have examined and compared both the in vitro growth characteristics of p53-deficient and Mdm2/p53-deficient fibroblasts, and the rate and spectrum of tumor formation in p53-deficient and Mdm2/p53-deficient mice. We find no difference between p53-deficient fibroblasts and Mdm2/p53-deficient fibroblasts either in their rate of proliferation in culture or in their survival frequency when treated with various genotoxic agents. Cell cycle studies indicate no difference in the ability of the two cell populations to enter S phase when treated with DNA-damaging agents or nucleotide antimetabolites, and p53-deficient fibroblasts and Mdm2/p53-deficient fibroblasts exhibit the same rate of spontaneous immortalization following long-term passage in culture. Finally, p53-deficient mice and Mdm2/p53-deficient mice display the same incidence and spectrum of spontaneous tumor formation in vivo. These results demonstrate that deletion of Mdm2 has no additional effect on cell proliferation, cell cycle control, or tumorigenesis when p53 is absent.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Cycle Cell Transformation, Neoplastic Neoplasms, Experimental Genetics Nuclear Proteins Proto-Oncogene Proteins Deficiency Tumor Suppressor Protein P53 Animals Cell Division Drug Effects Radiation Effects Cells, Cultured Crosses, Genetic Embryo, Mammalian Fibroblasts Cytology Gene Expression Regulation Genotype Heterozygote Mice Mice, Knockout Mitomycin Pharmacology Neoplasm Proteins Biosynthesis Physiopathology Proto-Oncogene Proteins C-mdm2 Ultraviolet Rays Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in