NDLI: A cellular 65-kDa protein recognizes the negative regulatory element of human papillomavirus late mRNA

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A cellular 65-kDa protein recognizes the negative regulatory element of human papillomavirus late mRNA

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A cellular 65-kDa protein recognizes the negative regulatory element of human papillomavirus late mRNA

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dietrich-goetz, W. Kennedy, I. M. Clements, J. B. Stanley, M. A. Levins, B.
Description	Author Affiliation: Dietrich-Goetz W ( Institute of Virology, University of Glasgow, Scotland.);
Abstract	Papillomavirus late gene expression is tightly linked to the differentiation state of the host cell. Levels of late mRNAs are only in part controlled by regulation of the late promoter, other posttranscriptional mechanisms exist that reduce the amount of late mRNA in undifferentiated cells. Previously we described a negative regulatory element (NRE) located upstream of the human papillomavirus type 16 late poly(A) site. We have delineated the NRE to a 79-nt region in which a G+U-rich region was the major determinant of NRE activity. UV-crosslinking assays identified a prominent nuclear protein of 65 kDa as the only factor in close contact with the NRE, and a complex of at least five proteins, including the 65-kDa protein, was enriched on NRE-RNA. Binding of the 65-kDa protein was depleted by preincubation with poly(U) Sepharose in high salt, a property characteristic of the U2 small nuclear ribonucleoprotein auxiliary factor U2AF65 and bacterially expressed U2AF65 exhibited NRE binding. The 65-kDa protein bound to the G+U-rich NRE 3' half which shows homology to the B2P2 sequence a known U2AF65 binding site in the alpha-tropomyosin gene, and the G+U-rich element can be replaced by B2P2 in the binding assay. Treatment of cells with phorbol 12-myristate 13-acetate reduced binding of the 65-kDa protein, induced NRE binding of a cytoplasmic protein, and relieved the NRE block on reporter gene expression.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Nuclear Proteins Papillomaviridae Genetics RNA, Messenger Metabolism RNA, Viral Regulatory Sequences, Nucleic Acid Ribonucleoproteins Binding Sites Cell Line Gene Expression Regulation Genes, Reporter HeLa Cells Keratinocytes Cytology Molecular Sequence Data Mutation Recombinant Proteins Tetradecanoylphorbol Acetate Pharmacology Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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