NDLI: A novel transporter involved in cobalt uptake

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A novel transporter involved in cobalt uptake

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Komeda, H. Shimizu, S. Kobayashi, M.
Description	Author Affiliation: Komeda H ( Department of Agricultural Chemistry, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Japan.);
Abstract	Cobalt is an essential component of a low molecular-mass nitrile hydratase (L-NHase) from Rhodococcus rhodochrous J1. We have found a new gene, nhlF, in the DNA region sandwiched between nhlBA encoding L-NHase and amdA encoding amidase, which are involved in the degradation of nitriles. The product of nhlF, NhlF, shows a significant sequence similarity with those of hoxN from Alcaligenes eutrophus, hupN from Bradyrhizobium japonicum, nixA from Helicobacter pylori, and ureH from Bacillus sp., which are considered to be involved in nickel uptake into these cells. Sequence and hydropathy plot analyses have shown that NhlF encodes a 352-amino acid (aa) protein with eight hydrophobic putative membrane-spanning domains. nhlF expression in R. rhodochrous ATCC 12674 and Escherichia coli JM109 confers uptake of 57Co in their cells, but not of 63Ni. The expression of both nhlF and nhlBA in R. rhodochrous ATCC 12674 exhibited higher NHase activity than nhlBA expression. These findings together with the inhibitory effect by uncouplers (CCCP and SF6847) for the cobalt uptake suggest that NhlF mediates the cobalt transport into the cell energy-dependently finally to provide L-NHase.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacterial Proteins Genetics Carrier Proteins Cation Transport Proteins Cobalt Metabolism Fungal Proteins Genes, Bacterial Membrane Proteins Rhodococcus Amino Acid Sequence Biological Transport Drug Effects Cations, Divalent Pharmacology Hydro-Lyases Biosynthesis Molecular Sequence Data Sequence Analysis, DNA Sequence Homology, Amino Acid Trans-Activators Transformation, Genetic Uncoupling Agents Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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