NDLI: YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene.

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YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene.

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YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aslam, F. Green, M. R. Guo, B. Lian, J. B. Van Wijnen, A. J. Frenkel, B. Stein, G. S. Deluca, H. Stein, J. L. Roberts, S. G.
Description	Author Affiliation: Guo B ( Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA.);
Abstract	The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. This interaction can be physiologically modulated by promoter context-specific transcription factors to facilitate optimal responsiveness of gene expression to hormone stimulation. One postulated regulatory mechanism involves the functional antagonism between hormone receptors and nonreceptor transcription factors interacting at the same hormone response element. Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene. We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity. We show that YY1 and vitamin D receptor (VDR)/retinoid X receptor heterodimers compete for binding at the osteocalcin VDRE. In addition, we find that YY1 interacts directly with TFIIB, and that one of the two tandemly repeated polypeptide regions of TFIIB spanning the basic domain is responsible for this interaction. TFIIB and VDR can also interact directly, and these factors synergize to mediate transactivation. Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bone And Bones Metabolism DNA-Binding Proteins Osteocalcin Genetics Receptors, Calcitriol Receptors, Retinoic Acid Transcription Factors Transcriptional Activation Vitamin D Pharmacology Animals Binding Sites Binding, Competitive Drug Effects Erythroid-Specific DNA-Binding Factors Models, Genetic Nuclear Proteins Biosynthesis Osteosarcoma Recombinant Proteins Retinoid X Receptors Transcription Factor TFIIB Transfection Tumor Cells, Cultured YY1 Transcription Factor Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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