NDLI: In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM.

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In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lightstone, L. Hargreaves, R. Aichinger, G. Bobek, G. Lombardi, G. Lechler, R. Peterson, M.
Description	Author Affiliation: Lightstone L ( Department of Immunology, Commonwealth Building, Royal Postgraduate Medical School, Du Cane Road, London, W12 0NN, England. llightst@rpms.ac.uk);
Abstract	The independent influences of invariant chain (Ii) and HLA-DM molecules on the array of naturally processed peptides displayed by HLA-DR molecules were studied using transfected cell lines. The absence of Ii led to an altered set of HLA-DR-bound peptides as judged by the discriminating responses of alloreactive T cell clones. While most T cell clones raised against DR+Ii+DM+ peripheral blood mononuclear cells (PBMC) failed to respond to DR+Ii-DM- cells, T cell clones raised against DR+Ii-DM- transfectants were not stimulated by DR+Ii+DM+ cells. Furthermore, coexpression of HLA-DM with HLA-DR1 in the absence of Ii augmented responses of anti-PBMC T cell clones but inhibited allorecognition by T cell clones raised against DR+Ii-DM- transfectants. The conformational integrity of the class II molecules, as judged by serology, suggests that the patterns of reactivity of the T cell clones reflect specificity for different alloantigen-bound peptides. Hence, discordant regulation of expression of major histocompatibility complex class II, Ii, and HLA-DM molecules in vivo may lead to the display of novel self-peptides and possible interruption of self-tolerance.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Differentiation, B-Lymphocyte Biosynthesis HLA-D Antigens HLA-DR Antigens Chemistry Histocompatibility Antigens Class II Antigen-Presenting Cells Immunology Antigens, CD Cell Line Epitopes Kinetics Protein Conformation Recombinant Proteins T-Lymphocytes Transfection Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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