NDLI: Alternative splicing of the human diacylglycerol kinase zeta gene in muscle.

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Alternative splicing of the human diacylglycerol kinase zeta gene in muscle.

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Alternative splicing of the human diacylglycerol kinase zeta gene in muscle.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mcintyre, T. M. Zimmerman, G. A. Topham, M. K. Bunting, M. Prescott, S. M. Ding, L.
Description	Author Affiliation: Ding L ( Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.);
Abstract	Diacylglycerol can function as a second messenger, and one mechanism for the attenuation of this signal is its conversion to phosphatidic acid, which is catalyzed by diacylglycerol kinase (DGK). We screened a cDNA library from human skeletal muscle and isolated two DGKzeta cDNAs that differed from the 3.5-kb clone originally identified in endothelial cells. One transcript, which was 3.4 kb long, was shown to be nonfunctional; it had a 77-bp deletion that included the translation initiation site. The other was 4.1 kb long with a unique 5' sequence of 853 bp. We also isolated a genomic clone of DGKzeta and determined its organization and location; it contains 32 exons, spans approximately 50 kb of genomic sequence, and maps to chromosome 11p11.2. The protein encoded by the 4.1-kb transcript contains two cysteine-rich regions, a catalytic domain, and ankyrin repeats like the endothelial form of DGKzeta, as well as a unique N-terminal domain. The coding sequence was shown to be derived from alternative splicing of the DGKzeta gene. In cells transfected with the 4.1-kb clone, we detected a 130-kDa protein with an antibody to DGKzeta and demonstrated that it was localized predominantly in the nucleus. We conclude that alternative splicing generates tissue-specific variants of DGKzeta that share some properties but may have unique ones as well.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Alternative Splicing Muscle, Skeletal Enzymology Phosphotransferases (Alcohol Group Acceptor) Biosynthesis Genetics Amino Acid Sequence Cloning, Molecular Diacylglycerol Kinase Exons Introns Molecular Sequence Data Molecular Weight Organ Specificity Chemistry Polymerase Chain Reaction Protein Biosynthesis Sequence Deletion Transcription, Genetic Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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