NDLI: From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1998 Volume: 95 Issue: 26

Year: 1998 Volume: 95 Issue: 25

Year: 1998 Volume: 95 Issue: 24

Year: 1998 Volume: 95 Issue: 23

Year: 1998 Volume: 95 Issue: 22

Year: 1998 Volume: 95 Issue: 21

Year: 1998 Volume: 95 Issue: 20

Year: 1998 Volume: 95 Issue: 19

Year: 1998 Volume: 95 Issue: 18

Year: 1998 Volume: 95 Issue: 17

Year: 1998 Volume: 95 Issue: 16

Year: 1998 Volume: 95 Issue: 15

Year: 1998 Volume: 95 Issue: 14

Year: 1998 Volume: 95 Issue: 13

Year: 1998 Volume: 95 Issue: 12

Year: 1998 Volume: 95 Issue: 11

Year: 1998 Volume: 95 Issue: 10

Year: 1998 Volume: 95 Issue: 9

Year: 1998 Volume: 95 Issue: 8

Year: 1998 Volume: 95 Issue: 7

Year: 1998 Volume: 95 Issue: 6

Year: 1998 Volume: 95 Issue: 5

Year: 1998 Volume: 95 Issue: 4

Lightning strikes twice: intron-intein coincidence.

Dynamical principles in biological processes.

Irregular arrays and randomization.

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.

Amber suppression in Escherichia coli by unusual mitochondria-like transfer RNAs.

Structural basis for methylesterase CheB regulation by a phosphorylation-activated domain.

Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter.

Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen.

Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells.

DNA-binding domains of Fos and Jun do not induce DNA curvature: An investigation with solution and gel methods

Characterization of the ATF/CREB site and its complex with GCN4.

Real-time enzyme kinetics monitored by dual-color fluorescence cross-correlation spectroscopy.

Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: high throughput screening for enzyme activity.

Monomolecular collapse of plasmid DNA into stable virus-like particles.

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

The complementary aggregation sites of fibrin investigated through examination of polymers of fibrinogen with fragment E.

An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter.

RNA polymerase of vesicular stomatitis virus specifically associates with translation elongation factor-1 alphabetagamma for its activity.

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.

Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation.

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.

Intermolecular cleavage by UmuD-like mutagenesis proteins.

Depletion of $Ca^{2+}$ from the sarcoplasmic reticulum of cardiac muscle prompts phosphorylation of phospholamban to stimulate store refilling

Is the molten globule a third phase of proteins?

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence.

Identification of hepatic nuclear factor 1 binding sites in the 5′ flanking region of the human phenylalanine hydroxylase gene: Implication of a dual function of phenylalanine hydroxylase stimulator in the phenylalanine hydroxylation system

Structure of a complex between a cap analogue and mRNA guanylyl transferase demonstrates the structural chemistry of RNA capping.

A unique glucose-dependent apoptotic pathway induced by c-Myc.

A combinatorial approach to the discovery of efficient cationic peptoid reagents for gene delivery.

Localization of F plasmid SopB protein to positions near the poles of Escherichia coli cells.

A previously unidentified host protein protects retroviral DNA from autointegration.

Electrophoresis in lyotropic polymer liquid crystals.

Reconstitution of hyperacetylated, DNase I-sensitive chromatin characterized by high conformational flexibility of nucleosomal DNA.

Escherichia coli NusA is required for efficient RNA binding by phage HK022 Nun protein

The pressure dependence of hydrophobic interactions is consistent with the observed pressure denaturation of proteins.

Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy.

Molecular picture of folding of a small α/β protein

Signaling pathways underlying eosinophil cell motility revealed by using caged peptides.

The variable domain of nonassembled Ig light chains determines both their half-life and binding to the chaperone BiP

Dynamics of surfactant release in alveolar type II cells.

Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains

Energy-transducing thylakoid membranes remain highly impermeable to ions during protein translocation.

Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency.

Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells.

Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5.

Inhibition of inositol 1,4,5-trisphosphate-induced $Ca^{2+}$ release by cAMP-dependent protein kinase in a living cell

Subcellular metabolic transients and mitochondrial redox waves in heart cells.

Modulation of intracellular transport by transported proteins: insight from regulation of COPI-mediated transport.

Menin, the product of the MEN1 gene, is a nuclear protein.

Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.

Blood-borne seeding by hematopoietic and endothelial precursors from the allantois.

Abundant microsatellite polymorphism in Saccharomyces cerevisiae, and the different distributions of microsatellites in eight prokaryotes and S. cerevisiae, result from strong mutation pressures and a variety of selective forces.

De novo insertion of an intron into the mammalian sex determining gene, SRY.

New Drosophila introns originate by duplication.

Expression of Xa1, a bacterial blight-resistance gene in rice, is induced by bacterial inoculation.

Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome.

Clonal heterogeneity at allelic methylation sites diagnostic for Prader-Willi and Angelman syndromes.

Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing.

Plant-pathogen microevolution: molecular basis for the origin of a fungal disease in maize.

Introns and intein coding sequence in the ribonucleotide reductase genes of Bacillus subtilis temperate bacteriophage SPbeta.

Identification of a silencing element in the human 15q11-q13 imprinting center by using transgenic Drosophila.

Use of D gene segments with irregular spacers in terminal deoxynucleotidyltransferase (TdT)+/+ and TdT-/- mice carrying a human Ig heavy chain transgenic minilocus.

Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge.

Deletion of Plasmodium berghei-specific CD4+ T cells adoptively transferred into recipient mice after challenge with homologous parasite.

Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction.

Primary CD8+ cells from HIV-infected individuals can suppress productive infection of macrophages independent of beta-chemokines.

A role for B cells in the development of T cell helper function in a malaria infection in mice.

Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.

Mapping a disease locus by allelic association.

Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4.

Impact of antigenemia on the bioactivity of infused anti-Tac antibody: implications for dose selection in antibody immunotherapies.

Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes.

Antisense inhibition of the PTI-1 oncogene reverses cancer phenotypes.

From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells.

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells.

Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet.

Synthesis and biological evaluation of cytotoxic analogs of somatostatin containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin.

Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model.

Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors.

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

Host-derived amino acids support the proliferation of symbiotic bacteria.

New protein kinase and protein phosphatase families mediate signal transduction in bacterial catabolite repression.

Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family.

Calibrated functional MRI: mapping the dynamics of oxidative metabolism.

An in vitro blood-brain barrier model: cocultures between endothelial cells and organotypic brain slice cultures.

Distinct functional stoichiometry of potassium channel beta subunits.

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity.

Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging.

Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia.

Rapping, a female receptive call, initiates male-female duets in the South African clawed frog.

A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX.

Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion

Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain.

Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke.

Molecular cloning and expression of the human delta7-sterol reductase.

Tagging with green fluorescent protein reveals a distinct subcellular distribution of L-type and non-L-type $Ca^{2+}$ channels expressed in dysgenic myotubes

Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.

Our ancestral physiological phenotype: an adaptation for hypoxia tolerance and for endurance performance?

Identification and characterization of a cell membrane nucleic acid channel.

HIV gp120 inhibits the somatotropic axis: a possible GH-releasing hormone receptor mechanism for the pathogenesis of AIDS wasting.

Ethylene-insensitive tobacco lacks nonhost resistance against soil-borne fungi.

MP2C, a plant protein phosphatase 2C, functions as a negative regulator of mitogen-activated protein kinase pathways in yeast and plants.

Characterization of a calmodulin-binding transporter from the plasma membrane of barley aleurone

Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana.

Where the imaginal appears real: a positron emission tomography study of auditory hallucinations.

Genetic traces of ancient demography.

Year: 1998 Volume: 95 Issue: 3

Year: 1998 Volume: 95 Issue: 2

Year: 1998 Volume: 95 Issue: 1

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bauer, C. Herzog, V. Hoffmann, J. Roch, J. M. Pietrzik, C. U. Stöber, K. Otero, D. A. Chen, C. Y.
Description	Author Affiliation: Pietrzik CU ( Institute for Cell Biology and Bonner Forum Biomedizn, University of Bonn, Ulrich-Haberland-Strasse 61 A, D-53121 Bonn, Germany.);
Abstract	In various species, thyrotropin (TSH) is known to stimulate both differentiation and proliferation of thyroid follicle cells. This cell type has also been shown to express members of the Alzheimer amyloid precursor (APP) protein family and to release the secretory N-terminal domain of APP (sAPP) in a TSH-dependent fashion. In this study on binding to the cell surfaces, exogenously added recombinant sAPP stimulated phosphorylation mediated by mitogen-activated protein kinase and effectively evoked proliferation in the rat thyroid epithelial cell line FRTL-5. To see whether this proliverative effect of sAPP is of physiological relevance, we used antisense techniques to selectively inhibit the expression of APP and the proteolytic release of sAPP by cells grown in the presence of TSH. The antisense-induced inhibition was detected by immunoblot, immunoprecipitation, and immunocytochemical analyses. After the reduced APP expression and sAPP secretion, we observed a strong suppression of the TSH-induced cell proliferation down to 35%. Recombinant sAPP but not TSH was able to overcome this antisense effect and to completely restore cell proliferation, indicating that sAPP acts downstream of TSH, in that it is released from thyroid epithelial cells during TSH-induced differentiation. We propose that sAPP operates as an autocrine growth factor mediating the proliferative effect of TSH on neighboring thyroid epithelial cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amyloid Beta-Protein Precursor Physiology Cell Differentiation Cell Division Thyroid Gland Cytology Thyrotropin Pharmacology Chemistry Animals Calcium-Calmodulin-Dependent Protein Kinases Metabolism Cell Compartmentation Cells, Cultured Epithelial Cells Growth Substances Molecular Sequence Data Oligonucleotides, Antisense RNA, Messenger Genetics Recombinant Proteins Solubility Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in