NDLI: Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5.

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Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oft, M. Bevec, D. Dascher, C. Schebesta, M. Schatz, O. Dobrovnik, M. Hauber, J. Jaksche, H. Rosorius, O.
Description	Author Affiliation: Schatz O ( Medical Policlinic, Pettenkoferstr. 8a, D-80336 Munich, Germany.);
Abstract	It has previously been shown that interaction of eukaryotic initiation factor 5A (eIF-5A) with the Rev trans-activator protein of HIV-1 mediates the transport of unspliced or incompletely spliced viral mRNAs across the nuclear envelope. Consequently, mutants of eIF-5A block Rev function and thereby replication of HIV-1 in trans, indicating that eIF-5A is a crucial protein that connects the viral Rev regulator with cellular RNA transport systems. Here we show that the ribosomal protein L5, which is the central protein component of the 5S rRNA export system, is a cellular interaction partner of eIF-5A. Functional studies demonstrate that overexpression of L5 protein significantly enhances Rev activity. Furthermore, Rev nuclear export activity is inhibited in human somatic cells by antibodies that recognize eIF-5A or L5. Our data suggest that the Rev export pathway shares components of a cellular transport system involved in the intracellular trafficking of polymerase III (5S rRNA) transcripts.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Products, Rev Metabolism HIV-1 Genetics Peptide Initiation Factors RNA, Viral RNA-Binding Proteins Ribosomal Proteins Amino Acid Sequence Biological Transport Cell Nucleus Gene Expression Regulation, Viral HeLa Cells Molecular Sequence Data Protein Binding Recombinant Proteins Chemistry Saccharomyces Cerevisiae Sequence Alignment Rev Gene Products, Human Immunodeficiency Virus Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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