NDLI: Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.

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Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.

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Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reiter, R. E. Thomas, G. Wahl, M. Witte, O. N. Davis, E. Szigeti, K. Loda, M. Gu, Z. Nisitani, S. Le Beau, M. M. Yamashiro, J. Watabe, T.
Description	Author Affiliation: Reiter RE ( Department of Urology, University of California, Los Angeles, CA 90095, USA. rreiter@urology.medsch.ucla.edu);
Abstract	The identification of cell surface antigens is critical to the development of new diagnostic and therapeutic modalities for the management of prostate cancer. Prostate stem cell antigen (PSCA) is a prostate-specific gene with 30% homology to stem cell antigen 2, a member of the Thy-1/Ly-6 family of glycosylphosphatidylinositol (GPI)-anchored cell surface antigens. PSCA encodes a 123-aa protein with an amino-terminal signal sequence, a carboxyl-terminal GPI-anchoring sequence, and multiple N-glycosylation sites. PSCA mRNA expression is prostate-specific in normal male tissues and is highly up-regulated in both androgen-dependent and -independent prostate cancer xenografts. In situ mRNA analysis localizes PSCA expression in normal prostate to the basal cell epithelium, the putative stem cell compartment of the prostate. There is moderate to strong PSCA expression in 111 of 126 (88%) prostate cancer specimens examined by in situ analysis, including high-grade prostatic intraepithelial neoplasia and androgen-dependent and androgen-independent tumors. Flow cytometric analysis demonstrates that PSCA is expressed predominantly on the cell surface and is anchored by a GPI linkage. Fluorescent in situ hybridization analysis localizes the PSCA gene to chromosome 8q24.2, a region of allelic gain in more than 80% of prostate cancers. A mouse homologue with 70% amino acid identity and similar genomic organization to human PSCA has also been identified. These results support PSCA as a target for prostate cancer diagnosis and therapy.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Neoplasm Immunology Antigens, Surface Membrane Glycoproteins Metabolism Neoplasm Proteins Neoplastic Stem Cells Prostate Prostatic Neoplasms Amino Acid Sequence Chromosome Mapping Chromosomes, Human, Pair 8 Cloning, Molecular GPI-Linked Proteins Gene Expression Regulation, Neoplastic Glycosylphosphatidylinositols Genetics Molecular Sequence Data Pathology RNA, Messenger Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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