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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vasan, S. Crijns, F. R. Boulanger, C. M. Wolffenbuttel, B. H. Poitevin, P. Ulrich, P. Egan, J. J. Huijberts, M. S. Cerami, A. Swennen, G. N. Lévy, B. I. |
| Description | Author Affiliation: Wolffenbuttel BH ( Department of Endocrinology, Cardiovascular Research Institute Maastricht and University (Hospital) Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.); |
| Abstract | Glucose and other reducing sugars react with proteins by a nonenzymatic, posttranslational modification process called nonenzymatic glycation. The formation of advanced glycation end products (AGEs) on connective tissue and matrix components accounts largely for the increase in collagen crosslinking that accompanies normal aging and which occurs at an accelerated rate in diabetes, leading to an increase in arterial stiffness. A new class of AGE crosslink 'breakers' reacts with and cleaves these covalent, AGE-derived protein crosslinks. Treatment of rats with streptozotocin-induced diabetes with the AGE-breaker ALT-711 for 1-3 weeks reversed the diabetes-induced increase of large artery stiffness as measured by systemic arterial compliance, aortic impedance, and carotid artery compliance and distensibility. These findings will have considerable implications for the treatment of patients with diabetes-related complications and aging. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 95 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1998-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carotid Artery, Common Physiopathology Collagen Metabolism Diabetes Mellitus, Experimental Glycosylation End Products, Advanced Hemodynamics Drug Effects Thiazoles Pharmacology Animals Blood Flow Velocity Blood Pressure Cardiac Output Physiology Cross-Linking Reagents Blood Heart Rate In Vitro Techniques Muscle, Smooth, Vascular Rats, Wistar Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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